ReviewTranslational pediatrics2017
Hypoglycemia in the preterm neonate: etiopathogenesis, diagnosis, management and long-term outcomes.
Review in Translational pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Efficacy of Oral Dextrose Gel for Neonatal Hypoglycaemia: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials With 4368 Patients.Endocrinology, diabetes & metabolism · 2026Pooled it
- Prevalence of prolonged transitional neonatal hypoglycemia and associated factors in Ethiopia: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Accuracy of continuous glucose monitoring in preterm infants: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Cerebral fuels within the first week of life in very preterm infants: a cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2026Trial
- Does the 3C (Counselling, Checking and Certification) Initiative Prevent Hypoglycemia Among At-Risk Stable Late Preterm and Term Neonates? - A Randomized Controlled Trial.Indian journal of pediatrics · 2025Trial
- Association between elevated blood glucose level and brain injuries (IVH/WMI) in preterm infants.BMC pediatrics · 2026Article
- Neonatal hypoglycemia and neurodevelopment outcomes among late preterm infants: a prospective cohort study.Pediatric research · 2026Article
- Recurrent Hypoglycemia in Two Late-Preterm Infants With Transitional Disorder of Glucose Mobilization-Case Series.Clinical case reports · 2026Article
- Preterm functional outcomes are reflected in early postnatal proteome changes.Pediatric research · 2026Article
- Neonatal Glycemic Status in Infants of Diabetic Mothers in Sulaimaniyah Governorate, Iraq.International journal of endocrinology and metabolism · 2026Article
- Incidence and Determinants of Newborn Hypoglycemia Among Neonates Hospitalized in Public Hospitals of Wolaita Zone, Southern Ethiopia: A Multicentered Prospective Follow-Up Study.International journal of pediatrics · 2026Article
- ECG parameters in episodes of neonatal hyper- and hypoglycemia: an observational study.Frontiers in pediatrics · 2026Article
- Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates.Neurophotonics · 2026Article
- In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia.Clinical science (London, England : 1979) · 2025Article
- Mediating role of preterm birth in the relationship between maternal disease and infant development.BMC pregnancy and childbirth · 2025Article
- Dynamic Interactions between the Gut Microbiome, Health, and Metabolic Disorders in Preterm Infants.Journal of microbiology and biotechnology · 2025Review
- Evaluation of commercial point-of-care glucometers for detection and monitoring of neonatal hypoglycemia in resource-constrained settings.BMC pediatrics · 2025Article
- Neonatal Hypoglycemia and Long-Term Pediatric Neurodevelopmental Outcomes: A Systematic Review.Cureus · 2025Review
- Positive Evolution of a Child Suffering from Caudal Regression Syndrome and Agenesia Sacra After Treatment with Growth Hormone and Rehabilitation.International journal of molecular sciences · 2025Article
- Impact of a structured food sequence and mobile health monitoring on gestational diabetes outcomes: a clinical trial.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose, like oxygen, is of fundamental importance for any living being and it is the major energy source for the fetus and the neonate during gestation. The placenta ensures a steady supply of glucose to the fetus, while birth marks a sudden change in substrate delivery and a major change in metabolism. Hypoglycemia is one of the most common pathologies encountered in the neonatal intensive care unit and affects a wide range of neonates. Preterm, small for gestational age (GA) and intra-uterine growth restricted neonates are especially vulnerable due to their lack of metabolic reserves and associated co-morbidities. Nearly 30-60% of these high-risk infants are hypoglycemic and require immediate intervention. Preterm neonates are uniquely predisposed to developing hypoglycemia and its associated complications due to their limited glycogen and fat stores, inability to generate new glucose using gluconeogenesis pathways, have higher metabolic demands due to a relatively larger brain size, and are unable to mount a counter-regulatory response to hypoglycemia. In this review we will discuss the epidemiology; pathophysiology; clinical presentation; management and neurodevelopmental outcomes in affected infants and summarize evidence to develop a rational and scientific approach to this common problem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.