Evidence map›Paper›PMID 29184703›Full record

ArticleWorld journal of gastrointestinal pathophysiology2017

Effects of commercially produced almond by-products on chemotherapy-induced mucositis in rats.

Alexandra L Whittaker, Ying Zhu, Gordon S Howarth, Chi S Loung, Susan E P Bastian, Michelle G Wirthensohn

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal pathophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alexandra L WhittakerSchool of Animal and Veterinary Sciences, the University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Ying ZhuSchool of Agriculture, Food and Wine, the University of Adelaide, Glen Osmond, SA 5064, Australia.
Gordon S HowarthSchool of Animal and Veterinary Sciences, the University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Chi S LoungSchool of Animal and Veterinary Sciences, the University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Susan E P BastianSchool of Agriculture, Food and Wine, the University of Adelaide, Glen Osmond, SA 5064, Australia.
Michelle G WirthensohnSchool of Agriculture, Food and Wine, the University of Adelaide, Glen Osmond, SA 5064, Australia.
University of Adelaide · AUWomen's and Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine if almond extracts reduce the severity of chemotherapy-induced mucositis as determined through biochemical, histological and behavioural markers.

methodsIntestinal mucositis is a debilitating condition characterized by inflammation and ulceration of the gastrointestinal mucosa experienced by cancer patients undergoing chemotherapy. Certain bioactive plant products have shown promise in accelerating mucosal repair and alleviating clinical symptoms. This study evaluated almond extracts for their potential to reduce the severity of chemotherapy-induced mucositis in Dark Agouti rats. Female Dark Agouti rats were gavaged (days 3-11) with either PBS, almond hull or almond blanched water extract at two doses, and were injected intraperitoneally with 5-fluorouracil (5-FU-150 mg/kg) or saline on day 9 to induce mucositis. Burrowing behavior, histological parameters and myeloperoxidase activity were assessed.

resultsBodyweight was significantly reduced in rats that received 5-FU compared to saline-treated controls (

conclusionAlmond extracts at these dosages offer little beneficial effect on mucositis severity. Burrowing provides a novel measure of affective state in studies of chemotherapy-induced mucositis.

Indexed as

5-FluorouracilAlmondBurrowingCancerMucositis

Identifiers

PMID29184703
PMCPMC5696615
OpenAlexW2767579677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.