Evidence map›Paper›PMID 29184626›Full record

ArticleJournal of extracellular vesicles2017

Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility.

Kenneth W Witwer, Carolina Soekmadji, Andrew F Hill, Marca H Wauben, Edit I Buzás, Dolores Di Vizio, Juan M Falcon-Perez, Chris Gardiner, Fred Hochberg, Igor V Kurochkin and 12 more

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Updating MISEV: When, What, How, and Why?Journal of extracellular vesicles · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Microfluidic Nanoparticle Separation for Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Article

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kenneth W WitwerDepartments of Molecular and Comparative Pathobiology and Neurology, The Johns Hopkins University School of Medicine, Baltimore, USAkwitwer1@jhmi.edu.ORCID 0000-0003-1664-4233
Carolina SoekmadjiDepartment of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0002-6920-6627
Andrew F HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.ORCID 0000-0001-5581-2354
Marca H WaubenDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Edit I BuzásDepartment of Genetics, Cell- and Immunobiology, Semmelweis University and MTA-SE Immunoproteogenomics Extracellular Vesicle Research Group, Budapest, Hungary.
Dolores Di VizioDivision of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences, and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Juan M Falcon-PerezExosomes Laboratory & Metabolomics Platform, CIC bioGUNE, CIBERehd, Derio, Spain.
Chris GardinerResearch Department of Haematology, University College London, London, UK.
Fred HochbergNeurosurgery, University of California at San Diego, San Diego, CA, USA.
Igor V KurochkinCentral Research Laboratories, Sysmex Co, Kobe, Japan.
Jan LötvallCodiak BioSciences, Cambridge, MA, USA.ORCID 0000-0001-9195-9249
Suresh MathivananDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Rienk NieuwlandDepartment of Clinical Chemistry and Vesicle Observation Centre, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
Susmita SahooDepartment of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hidetoshi TaharaDepartment of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Ana Claudia TorrecilhasDepartamento de Ciências Farmacêuticas, UNIFESP, Diadema, Brazil.
Alissa M WeaverDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0002-4096-8636
Hang YinCenter of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, China.
Lei ZhengDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
Yong Song GhoDepartment of Life Sciences, POSTECH (Pohang University of Science and Technology), Pohang, South Korea.
Peter QuesenberryBrown Medical School, Rhode Island Hospital, Providence, RI, USA.
Clotilde ThéryInstitut Curie, INSERM U932, PSL Research University, Paris, Franceclotilde.thery@curie.fr.

Funding

Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine AbuseR01DA040385 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2015 to 2019
$2.3M
Exosome-Filopodia InteractionsR01GM117916 · NIGMS · VANDERBILT UNIVERSITY · PI WEAVER, ALISSA M · 2016 to 2019
$2.0M
Discovering novel players in mechanisms of extracellular vesicle release, cargo loading, and early pathogenesis of late-onset Alzheimer's DiseaseR56AG057430 · NIA · JOHNS HOPKINS UNIVERSITY · PI CHENG, LINZHAO, MACHAIRAKI, VASILIKI · 2017 to 2017
$796k
NIA NIH HHS R56 AG057430NIDA NIH HHS R01 DA040385NIGMS NIH HHS R01 GM117916
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID29184626
PMCPMC5698937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.