ReviewFrontiers in plant science2017
Metabolic Origins and Transport of Vitamin E Biosynthetic Precursors.
Review in Frontiers in plant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing.Journal of integrative plant biology · 2026Review
- Total tocopherol levels in maize grain depend on chlorophyll biosynthesis within the embryo.BMC plant biology · 2025Article
- A family of α/β hydrolases removes phytol from chlorophyll metabolites for tocopherol biosynthesis in Arabidopsis.The Plant cell · 2025Article
- Tocotrienols in Eleven Species ofMolecules (Basel, Switzerland) · 2025Article
- Molecular characterization of homogentisate phytyltransferase and methylphytylbenzoquinol methyltransferase genes from olive fruit with regard to the tocopherol content and the response to abiotic stresses.Frontiers in plant science · 2025Article
- Review
- Genome-wide association identifies a missing hydrolase for tocopherol synthesis in plants.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Metabolic Pathway of Natural Antioxidants, Antioxidant Enzymes and ROS Providence.Antioxidants (Basel, Switzerland) · 2022Review
- Vitamin E synthesis and response in plants.Frontiers in plant science · 2022Review
- Effect of fruit shading and cold storage on tocopherol biosynthesis and its involvement in the susceptibility of Star Ruby grapefruit to chilling injury.Food chemistry. Molecular sciences · 2021Article
- Antioxidant and Signaling Role of Plastid-Derived Isoprenoid Quinones and Chromanols.International journal of molecular sciences · 2021Review
- The Role of Membranes and Lipid-Protein Interactions in the Mg-Branch of Tetrapyrrole Biosynthesis.Frontiers in plant science · 2021Review
- Regulation of Tocopherol Biosynthesis During Fruit Maturation of DifferentFrontiers in plant science · 2021Article
- Genome-wide association analysis of natural variation in seed tocochromanols of barley.The plant genome · 2020Article
- High throughput profiling of tocochromanols in leaves and seeds of Arabidopsis and Maize.Plant methods · 2020Article
- Strategies for the production of biochemicals in bioenergy crops.Biotechnology for biofuels · 2020Review
- RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses.Chemical research in toxicology · 2019Review
- Effects of nitrogen fertilization rate on tocopherols, tocotrienols and γ-oryzanol contents and enzymatic antioxidant activities in rice grains.Physiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Vitamin E Biosynthesis and Its Regulation in Plants.Antioxidants (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tocochromanols are organic compounds mostly produced by photosynthetic organisms that exhibit vitamin E activity in animals. They result from the condensation of homogentisate with four different polyprenyl side chains derived all from geranylgeranyl pyrophosphate. The core tocochromanol biosynthesis has been investigated in several photosynthetic organisms and is now well-characterized. In contrast, our current knowledge of the biosynthesis and transport of tocochromanol biosynthetic precursors is much more limited. While tocochromanol synthesis occurs in plastids, converging genetic data in Arabidopsis and soybean demonstrate that the synthesis of the polar precursor homogentisate is located in the cytoplasm. These data implies that tocochromanol synthesis involves several plastidic membrane transporter(s) that remain to be identified. In addition, the metabolic origin of the lipophilic isoprenoid precursor is not fully elucidated. While some genetic data exclusively attribute the synthesis of the prenyl component of tocochromanols to the plastidic methyl erythritol phosphate pathway, multiple lines of evidence provided by feeding experiments and metabolic engineering studies indicate that it might partially originate from the cytoplasmic mevalonate pathway. Although this question is still open, these data demonstrate the existence of membrane transporter(s) capable of importing cytosolic polyprenyl pyrophosphate such as farnesyl pyrophosphate into plastids. Since the availability of both homogentisate and polyprenyl pyrophosphates are currently accepted as major mechanisms controlling the type and amount of tocochromanols produced in plant tissues, we summarized our current knowledge and research gaps concerning the biosynthesis, metabolic origins and transport of tocochromanol biosynthetic precursors in plant cells.
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