ArticleFrontiers in endocrinology2017
Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment.
Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03095963 (Effects of Probiotics Assumption on Serum Thyroid Hormone and TSH Levels in Hypothyroid Patients on Levothyroxine Treatment), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Probiotics Assumption on Serum Thyroid Hormone and TSH Levels in Hypothyroid Patients on Levothyroxine Treatment
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- The relationship between thyroid and human-associated microbiota: A systematic review of reviews.Reviews in endocrine & metabolic disorders · 2024Pooled it
- Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials.PloS one · 2024Pooled it
- The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial.PloS one · 2023Trial
- Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy.Frontiers in endocrinology · 2022Trial
- Lactobacillus in autoimmune thyroid diseases: benefit or risk?Frontiers in immunology · 2026Review
- Changes in gut microbiota before and after treatment in patients with primary hypothyroidism.Open life sciences · 2026Article
- The impact of thyroid disorders on the gut microbiome: emerging mechanisms and clinical relevance.Archives of endocrinology and metabolism · 2025Review
- Drugs Versus Microbiota: How Pharmacotherapy Affects Gut and Probiotic Bacteria.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Effects of probiotics and synbiotics oral supplementation on thyroid function in adults: a grade-assessed systematic review and meta-analysis.Thyroid research · 2025Review
- Gut microbiome versus thyroid cancer: Association and clinical implications (Review).Oncology letters · 2025Review
- Gut microbiota alteration was related to subclinical hypothyroidism and dyslipidemia in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers.Gut microbes reports · 2025Review
- Microbiota dysbiosis impact on the metabolism of T3 and T4 hormones and its association with thyroid cancer.Frontiers in cell and developmental biology · 2025Review
- Gut microbiota in hypothyroidism: pathogenic mechanisms and opportunities for precision microbiome interventions.Frontiers in microbiology · 2025Review
- Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis.Clinical and experimental medicine · 2024Review
- Evaluation of Fasting and Probiotics in Reducing Postweaning Stress in Rabbits: Study of their Effects on Biochemical and Gene expression Patterns.Applied biochemistry and biotechnology · 2024Article
- Cross-talk between the gut microbiota and hypothyroidism: a bidirectional two-sample Mendelian randomization study.Frontiers in nutrition · 2024Article
- Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions.Frontiers in cellular and infection microbiology · 2024Review
- Microbiota Composition and Probiotics Supplementations on Sleep Quality-A Systematic Review and Meta-Analysis.Clocks & sleep · 2023Review
- Relationship between gut microbiota and thyroid function: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe relationship between probiotics and levothyroxine (LT
methodsA prospective, randomized, single-blind, controlled, investigator-started clinical trial was carried out. Patients with primary hypothyroidism were randomly assigned to the study (VSL#3
resultsThirty-nine patients were enrolled in the study group and 41 in the control group. No difference in thyroid function [thyroid-stimulating hormone (TSH), free triiodothyronine (fT
conclusionVSL#3 CLINICALTRIALSGOV ID: Registration number NCT03095963.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.