ArticleFrontiers in physiology2017
Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Hypothalamic Inflammaging: A Central Driver of Type 2 Diabetes Mellitus and Metabolic Disease in Aging.Diabetes & metabolism journal · 2026Review
- Brain Defense of Glycemia in Health and Diabetes.Diabetes · 2024Review
- Metabolic regulation of single synaptic vesicle exo- and endocytosis in hippocampal synapses.Cell reports · 2024Article
- Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation.The Journal of cell biology · 2024Article
- Article
- Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity.Nature communications · 2023Article
- Carotid body: an emerging target for cardiometabolic co-morbidities.Experimental physiology · 2023Review
- Activation of POMC neurons to adiponectin participating in EA-mediated improvement of high-fat diet IR mice.Frontiers in neuroscience · 2023Article
- The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis.Cell & bioscience · 2022Review
- Central nervous system regulation of organismal energy and glucose homeostasis.Nature metabolism · 2021Review
- Neonatal Hypoglycemia and Brain Vulnerability.Frontiers in endocrinology · 2021Review
- Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices.Frontiers in synaptic neuroscience · 2021Article
- Cellular and systemic mechanisms for glucose sensing and homeostasis.Pflugers Archiv : European journal of physiology · 2020Review
- Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission.Nature communications · 2020Article
- TRPC channels: Structure, function, regulation and recent advances in small molecular probes.Pharmacology & therapeutics · 2020Review
- Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism.Frontiers in endocrinology · 2020Review
- The circadian regulation of food intake.Nature reviews. Endocrinology · 2019Review
- Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Revisiting How the Brain Senses Glucose-And Why.Cell metabolism · 2019Review
- Sensing Glucose in the Central Melanocortin Circuits of Rainbow Trout: A Morphological Study.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothalamus have been recognized for decades as one of the major brain centers for the control of energy homeostasis. This area contains specialized neurons able to detect changes in nutrients level. Among them, glucose-sensing neurons use glucose as a signaling molecule in addition to its fueling role. In this review we will describe the different sub-populations of glucose-sensing neurons present in the hypothalamus and highlight their nature in terms of neurotransmitter/neuropeptide expression. This review will particularly discuss whether pro-opiomelanocortin (POMC) neurons from the arcuate nucleus are directly glucose-sensing. In addition, recent observations in glucose-sensing suggest a subtle system with different mechanisms involved in the detection of changes in glucose level and their involvement in specific physiological functions. Several data point out the critical role of reactive oxygen species (ROS) and mitochondria dynamics in the detection of increased glucose. This review will also highlight that ATP-dependent potassium (K
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