ArticleInternational journal of general medicine2017
Prevalence and association of vitamin D deficiency and mortality in patients with severe sepsis.
Article in International journal of general medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Vitamin D supplementation and mortality among critically ill adults: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effects of different vitamins on individuals with septic shock: a Bayesian NMA of RCTs.Frontiers in nutrition · 2025Pooled it
- Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis.BMC infectious diseases · 2020Pooled it
- Admission 25-Hydroxyvitamin D Deficiency Is Associated with Poor Outcomes in ICU Patients with Sepsis-Associated Encephalopathy (SAE).Journal of clinical medicine · 2026Article
- Long-term bone metabolism outcomes in critically Ill patients with sepsis: a prospective series study.BMC infectious diseases · 2026Article
- sTREM-1, HMGB1, CRP, PCT, sCD14-ST, IL-6, IL-10, sHLA-G, and Vitamin D in Relation to Clinical Scores and Survival in SIRS/Sepsis.Biomedicines · 2025Article
- Vitamin D supplementation can improve the 28-day mortality rate in patients with sepsis-associated acute kidney injury.Renal failure · 2024Article
- Observational
- Assessment of 28-day survival of patients with sepsis based on vitamin D status: a hospital-based prospective cohort study in Indonesia.The Pan African medical journal · 2023Article
- Delta-Procalcitonin and Vitamin D Can Predict Mortality of Internal Medicine Patients with Microbiological Identified Sepsis.Medicina (Kaunas, Lithuania) · 2021Article
- A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review.Journal of inflammation research · 2021Review
- Association of Serum Levels of Vitamin D with Blood Pressure Status in Northern Iranian Population: The PERSIAN Guilan Cohort Study (PGCS).International journal of general medicine · 2020Article
- The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review.Patient related outcome measures · 2020Review
- The significance of the vitamin D metabolism in the development of periprosthetic infections after THA and TKA: a prospective matched-pair analysis of 240 patients.Clinical interventions in aging · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D is a steroid prohormone that regulates body calcium and phosphate metabolism. Recent studies have shown an association between low vitamin D status and high mortality in patients admitted to intensive care units. To date, there are limited data available specifically about severely septic patients in medical units.
objectivesTo determine the prevalence of vitamin D deficiency in severely septic patients and its clinical outcomes, including mortality rate.
methodsA prospective observational study was conducted to investigate the prevalence of vitamin D deficiency and its association with 30-day mortality in patients with severe sepsis. Patients admitted to medical wards at our hospital between November 2014 and March 2015 were included in the study. A 25-hydroxyvitamin D level <20 ng/mL was defined as vitamin D deficiency, and <12 ng/mL as severe deficiency. For an association analysis, the patients were grouped into deficient versus not deficient and severely deficient versus not severely deficient.
resultsOne hundred and ten eligible patients were enrolled. A total of 83 patients (75%) had vitamin D deficiency and 42 (38%) had severe deficiency. Despite an insignificant higher 30-day hospital mortality rate in vitamin D deficient versus non-deficient groups (16% vs 4%,
conclusionThe prevalence of vitamin D deficiency was very high in three-quarters of patients with severe sepsis. A significant higher mortality rate was observed, particularly in patients with severe vitamin D deficiency.
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