ArticleInternational journal of nanomedicine2017
Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Trial
- Valorization of Hot Trub: Extraction and Nanoparticle Encapsulation for Antitumor Applications.Chemistry & biodiversity · 2026Article
- Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template.Drug delivery and translational research · 2026Article
- Fabrication and Characterization of Kafirin Microparticles Made Using Ionic Gelation Vibrational Jet Flow Technology: Influence of Processing Parameters on Physicochemical Properties.Journal of food science · 2026Article
- Article
- Prodigiosin/celecoxib-loaded into zein/sodium caseinate nanoparticles as a potential therapy for triple negative breast cancer.Scientific reports · 2024Article
- Nanofibers based on zein protein loaded with tungsten oxide for cancer therapy: fabrication, characterization and in vitro evaluation.Scientific reports · 2023Article
- Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic fungal infections.Drug delivery and translational research · 2023Article
- Review
- Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer.Drug delivery · 2020Article
- Bio-Based Nanoparticles as a Carrier of β-Carotene: Production, Characterisation and In Vitro Gastrointestinal Digestion.Molecules (Basel, Switzerland) · 2020Article
- Interfacial Engineering of Pickering Emulsion Co-Stabilized by Zein Nanoparticles and Tween 20: Effects of the Particle Size on the Interfacial Concentration of Gallic Acid and the Oxidative Stability.Nanomaterials (Basel, Switzerland) · 2020Article
- A new design for obtaining of white zein micro- and nanoparticles powder: antisolvent-dialysis method.Food science and biotechnology · 2020Article
- Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice.Toxicology reports · 2020Article
- Synthesis of rotenone loaded zein nano-formulation for plant protection against pathogenic microbes.RSC advances · 2019Article
- The Effect of Size, Dose, and Administration Route on Zein Nanoparticle Immunogenicity in BALB/c Mice.International journal of nanomedicine · 2019Article
- α-Bisabolol-Loaded Cross-Linked Zein Nanofibrous 3D-Scaffolds For Accelerating Wound Healing And Tissue Regeneration In Rats.International journal of nanomedicine · 2019Article
- Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system.International journal of nanomedicine · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, the fabrication of size-controlled zein particles has been a challenging issue. In this study, a modified anti-solvent precipitation method was developed, and the effects of various factors, such as mixing method, solvent/anti-solvent ratio, temperature, zein concentrations and the presence of sodium caseinate (SC) on properties of zein particles were investigated. Evidence is presented that, among the previously mentioned factors, the mixing method, especially mixing rate, could be used as an effective parameter to control the size of zein particles without changing other parameters. Moreover, through fine-tuning the mixing rate together with zein concentration, particles with sizes ranging from nanometers to micrometers and low polydispersity index values could be easily obtained. Based on the size-controlled fabrication method, SC-coated zein nanoparticles could also be obtained in a size-controlled manner by incubation of the coating material with the already-formed zein particles. The resultant nanoparticles showed better performance in both drug loading and controlled release, compared with zein/SC hybrid nanoparticles fabricated by adding aqueous ethanol solution to SC solution. The possible mechanisms of the nanoprecipitation process and self-assembly formation of these nanoparticles are discussed.
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