Evidence map›Paper›PMID 29184394›Full record

ArticlePatient preference and adherence2017

Highly specific reasons for nonadherence to antiretroviral therapy: results from the German adherence study.

Johanna Boretzki, Eva Wolf, Carmen Wiese, Sebastian Noe, Annamaria Balogh, Anja Meurer, Ivanka Krznaric, Alexander Zink, Christian Lersch, Christoph D Spinner

Abstract read
In one paragraph

Article in Patient preference and adherence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
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  7. Genetic VariantPharmaceutics · 2022
    Article
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  9. Review
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  11. Article
  12. Article
  13. Article
  14. A Descriptive Study of HIV Patients Highly Adherent to Antiretroviral.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020
    Article
  15. Article
  16. Article
  17. Observational
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Johanna BoretzkiDepartment of Medicine II, University Hospital Klinikum rechts der Isar, Munich.
Eva WolfMUC Research, Munich.
Carmen WieseMVZ Karlsplatz, HIV Clinical Care Center, Munich.
Sebastian NoeMVZ Karlsplatz, HIV Clinical Care Center, Munich.
Annamaria BaloghMUC Research, Munich.
Anja MeurerCenter for Infectiology and Internal Medicine, Munich.
Ivanka KrznaricCenter for Infectiology Prenzlauer Berg, Berlin.
Alexander ZinkDepartment of Dermatology and Allergology, University Hospital Klinikum rechts der Isar, Munich, Germany.
Christian LerschDepartment of Medicine II, University Hospital Klinikum rechts der Isar, Munich.
Christoph D SpinnerDepartment of Medicine II, University Hospital Klinikum rechts der Isar, Munich.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReasons for and frequency of nonadherence to antiretroviral therapy (ART) may have changed due to pharmacological improvements. In addition, the importance of known non-pharmacologic reasons for nonadherence is unclear.

methodsWe performed a cross-sectional, noninterventional, multicenter study to identify current reasons for nonadherence. Patients were categorized by physicians into the following adherence groups: good, unstable, or poor adherence. Co-variables of interest included age, sex, time since HIV diagnosis, ART duration, current ART regimen, HIV transmission route, comorbidity, HIV-1 RNA viral load (VL), and CD4 cell count. Patients self-reported the number of missed doses and provided their specific reasons for nonadherent behavior. Statistical analyses were performed using Fisher's extended exact test, Kruskal-Wallis test, and logistic regression models.

resultsOur study assessed 215 participants with good (n=162), unstable (n=36), and poor adherence (n=17). Compared to patients with good adherence, patients with unstable and poor adherence reported more often to have missed at least one dose during the last week (good 11% vs unstable 47% vs poor 63%,

conclusionIdentification of factors associated with poor adherence helps in identifying patients with a higher risk for nonadherence. Reasons for nonadherence should be directly addressed in every patient, because they are common and constitute possible adherence intervention points.

Indexed as

adherenceantiretroviral therapyARTHIVhuman immunodeficiency virusnonadherencepatients’ beliefs

Identifiers

PMID29184394
PMCPMC5687417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.