Evidence map›Paper›PMID 29184211›Full record

ReviewNature neuroscience2017

Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

Stephan J Sanders, Benjamin M Neale, Hailiang Huang, Donna M Werling, Joon-Yong An, Shan Dong, Whole Genome Sequencing for Psychiatric Disorders (WGSPD), Goncalo Abecasis, P Alexander Arguello, John Blangero and 19 more

Erratum issuedAbstract readReview
In one paragraph

Review in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Article
  5. Frontiers in behavioral neuroscience · 2026
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  9. An Update on the Genetics of IgA Nephropathy.Journal of clinical medicine · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Stephan J SandersDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Benjamin M NealeAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1513-6077
Hailiang HuangAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1461-5762
Donna M WerlingDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Joon-Yong AnDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8839-6297
Shan DongDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Whole Genome Sequencing for Psychiatric Disorders (WGSPD)
Goncalo AbecasisDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
P Alexander ArguelloNational Institute of Mental Health, Bethesda, MD, USA.ORCID 0000-0002-7709-8697
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, School of Medicine, Brownsville, TX, USA.
Michael BoehnkeDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Mark J DalyAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0949-8752
Kevin EgganStanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Daniel H GeschwindDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
David C GlahnDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
David B GoldsteinInstitute for Genomic Medicine, Columbia University Medical Center, Hammer Health Sciences, New York, NY, USA.
Raquel E GurDepartment of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert E HandsakerStanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0002-3128-3547
Steven A McCarrollStanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Roel A OphoffBrain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-8287-6457
Aarno PalotieStanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Carlos N PatoDepartment of Psychiatry, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chiara SabattiDepartment of Health Research and Policy, Division of Biostatistics, Stanford University, Stanford, CA, USA.
Matthew W StateDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
A Jeremy WillseyDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Steven E HymanStanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. seh@harvard.edu.ORCID 0000-0002-3628-2359
Anjene M AddingtonDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. anjene.addington@nih.gov.ORCID 0000-0001-7770-299X
Thomas LehnerDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. tlehner@mail.nih.gov.
Nelson B FreimerCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA. nfreimer@mednet.ucla.edu.ORCID 0000-0003-3586-6587

Funding

Genomic Psychiatry CohortR01MH085548 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PATO, CARLOS N, PATO, MICHELE T · 2008 to 2012
$16.3M
Whole Genome Sequencing for Schizophrenia and Bipolar Disorder in the GPCU01MH105641 · NIMH · BROAD INSTITUTE, INC. · PI MCCARROLL, STEVEN ANDREW · 2014 to 2018
$13.6M
1/2 Genomic Strategies to Identify High-impact Psychiatric Risk VariantsU01MH105578 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., GESCHWIND, DANIEL H · 2014 to 2018
$8.5M
1/3-ldentifying regulatory mutations that influence neuropsychiatric diseaseU01MH105670 · NIMH · DUKE UNIVERSITY · PI GOLDSTEIN, DAVID B. · 2014 to 2018
$5.9M
2/3-Identifying regulatory mutations that influence neuropsychiatric diseaseU01MH105575 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STATE, MATTHEW W. · 2014 to 2018
$5.7M
3/3-Identifying regulatory mutations that influence neuropsychiatric diseaseU01MH105669 · NIMH · BROAD INSTITUTE, INC. · PI DALY, MARK JOSEPH · 2014 to 2018
$4.5M
2/3: Pedigree-Based Whole Genome Sequencing of Affective and Psychotic DisordersU01MH105632 · NIMH · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BLANGERO, JOHN · 2015 to 2018
$4.2M
4/4 The Autism Sequencing Consortium: Autism gene discovery in the >20,000 exomes (supplement)U01MH100239 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STATE, MATTHEW W. · 2013 to 2015
$3.0M
Whole Genome Sequencing for Schizophrenia and Bipolar Disorder in the GPCU01MH105653 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L · 2014 to 2018
$2.8M
Genome Sequencing in Extended Bipolar PedigreesR01MH095454 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2012 to 2014
$2.4M
1/3:Pedigree-Based Whole Genome Sequencing of Affective and Psychotic DisordersU01MH105630 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2015 to 2018
$1.4M
2/2 Genomic strategies to identify high-impact psychiatric risk variantsU01MH105666 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PALOTIE, AARNO · 2014 to 2018
$1.0M
NIMH NIH HHS R01 MH085548NIMH NIH HHS R01 MH095454NIMH NIH HHS U01 MH100239NIMH NIH HHS U01 MH105573NIMH NIH HHS U01 MH105575NIMH NIH HHS U01 MH105578NIMH NIH HHS U01 MH105630NIMH NIH HHS U01 MH105632NIMH NIH HHS U01 MH105634NIMH NIH HHS U01 MH105641NIMH NIH HHS U01 MH105653NIMH NIH HHS U01 MH105666NIMH NIH HHS U01 MH105669NIMH NIH HHS U01 MH105670
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biological PsychiatryGenetic VariationGenome, HumanHumansMental DisordersWhole Genome Sequencing

Identifiers

PMID29184211
PMCPMC7785336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.