ArticleNature neuroscience2017
Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed.
- Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressure.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Parvalbumin interneurons contribute to spontaneous hemodynamic fluctuations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Behavior Differentially Shapes Spontaneous Cortical Network Dynamics Across Frequencies.bioRxiv : the preprint server for biology · 2026Article
- Brain motion is driven by mechanical coupling with the abdomen.Nature neuroscience · 2026Article
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- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
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- A cortex-wide multimodal microscope for simultaneous CaNature communications · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CaBLAM! A high-contrast bioluminescent CabioRxiv : the preprint server for biology · 2025Article
- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
- Two fast algorithms for finding the solution of the lower Hessenberg quasi-Toeplitz linear system from Markov chain.Scientific reports · 2025Article
- Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Tetherless miniaturized point detector device for monitoring cortical surface hemodynamics in mice.Journal of biomedical optics · 2025Article
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Whole-brain causal discovery using fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.