ArticleNature neuroscience2017
Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
85 citing papers in PubMed, 116 citations in OpenAlex.
- TRPA1 Channels as Multimodal Environmental Sensors: Structure-Function Insights From Aquatic Organisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Backward scrunching: planarians escape from noxious stimuli, cannibalism, and predation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- The Cellular and Circuit Basis of Temperature Sensation inAnnual review of neuroscience · 2026Review
- Coordinated molecular and physiological adaptations enable activity at sub-freezing temperatures in the snow fly Chionea alexandriana.Current biology : CB · 2026Article
- The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Thermal Stress-Induced Alterations to Oxylipin Signal Receptors in the Cnidarian-Dinoflagellate Symbiosis.Environmental microbiology · 2026Article
- Pharmacological Effects of NADPH Oxidase Inhibitors on Butterfly Wing Morphogenesis and Color Pattern Formation inInsects · 2026Article
- Genomic Exaptation and Regulatory Landscape Shifts as Key Mechanisms Enabling Flatworm Terrestrialization.Genome biology and evolution · 2026Article
- Capsaicin responses in Drosophila: Exploring the possibility of establishing a new Non-TRPV1 model.Biochemistry and biophysics reports · 2026Review
- Mechanostimulation of neuroendocrine cells and their clinical relevance.Molecular and cellular biochemistry · 2026Review
- TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026Article
- STIM1 functionally couples to transient receptor potential ankyrin 1 contributing to nociception.Pain · 2025Article
- Red Midge Larvae Are an Invertebrate Alternative Diet to Beef Liver for Planarian Husbandry.Biomolecules · 2025Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Hot breath, quick exit: aphids flee mammalian heat via TRPA1.Science China. Life sciences · 2025Article
- Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan.Nature metabolism · 2025Article
- Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids.bioRxiv : the preprint server for biology · 2025Article
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- Cross-modal sensory compensation increases mosquito attraction to humans.Science advances · 2025Article
- Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
All animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is not well understood. Here we show that noxious heat and irritant chemicals elicit robust escape behaviors in the planarian Schmidtea mediterranea and that the conserved ion channel TRPA1 is required for these responses. TRPA1-mutant Drosophila flies are also defective in noxious-heat responses. We find that either planarian or human TRPA1 can restore noxious-heat avoidance to TRPA1-mutant Drosophila, although neither is directly activated by heat. Instead, our data suggest that TRPA1 activation is mediated by H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.