ArticleNature communications2017
Bacterial endosymbionts influence host sexuality and reveal reproductive genes of early divergent fungi.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed, 105 citations in OpenAlex.
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- Light restores sporulation in Rhizopus microsporus cured of its endosymbionts, unveiling their role in fitness and virulence.The ISME journal · 2026Article
- Lineage-specific endosymbiosis in Mucorales: restriction ofCurrent research in microbial sciences · 2026Article
- Endosymbiotic interactions in the fungal kingdom: a framework for progressive endosymbiosis.Frontiers in microbiology · 2026Review
- Microbial network assembly in bat flies with differing host specificity from North Africa.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Comparative Genomics Reveals Multipartite Genomes Undergoing Loss in the Fungal Endosymbiotic Genus Mycetohabitans.Genome biology and evolution · 2025Article
- Unveiling a pervasive DNA adenine methylation regulatory network in the early-diverging fungus Rhizopus microsporus.Nature communications · 2025Article
- Endobacteria Have a Negative Effect on the Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- A genomic perspective on fungal diversity and evolution.Nature reviews. Microbiology · 2025Review
- Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus.Nature communications · 2025Article
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- Endofungal bacteria as hidden facilitators of biotic interactions.The ISME journal · 2025Review
- Diversity analysis of endohyphal bacteria in oil-producing fungi inhabiting arid environments.Frontiers in microbiology · 2025Article
- Tomato rot byFrontiers in microbiology · 2025Article
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- Symbioses between fungi and bacteria: from mechanisms to impacts on biodiversity.Current opinion in microbiology · 2024Review
- Prevalence and diversity of TAL effector-like proteins in fungal endosymbioticMicrobial genomics · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here, we explore this prediction in the mutualism between the fungus Rhizopus microsporus (Rm, Mucoromycotina) and a beta-proteobacterium Burkholderia, which controls host asexual reproduction. We show that reproductive addiction of Rm to endobacteria extends to mating, and is mediated by the symbiont gaining transcriptional control of the fungal ras2 gene, which encodes a GTPase central to fungal reproductive development. We also discover candidate G-protein-coupled receptors for the perception of trisporic acids, mating pheromones unique to Mucoromycotina. Our results demonstrate that regulating host asexual proliferation and modifying its sexual reproduction are sufficient for the symbiont's control of its own transmission, needed for antagonism-to-mutualism transition in heritable symbioses. These properties establish the Rm-Burkholderia symbiosis as a powerful system for identifying reproductive genes in Mucoromycotina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.