ArticleNature communications2017
Label-free nanoscale optical metrology on myelinated axons in vivo.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Myelin Dynamics at the Axon-Oligodendrocyte Interface: Adaptive Conduction Homeostasis in Demyelination, Remyelination and White Matter Repair.International journal of molecular sciences · 2026Review
- Simultaneous three-photon and optical coherence microscopy deep within an intact mouse brain.Npj imaging · 2026Article
- Measurement of the absolute value of the optical birefringence of myelin in primate brain tissue.Neurophotonics · 2026Article
- Advances in multiscale myelin imaging: from classical histology to functional insights.Frontiers in cellular neuroscience · 2026Review
- Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury.Neurophotonics · 2025Article
- Establishment of a Serum-Free Human iPSC-Derived Model of Peripheral Myelination.ACS biomaterials science & engineering · 2024Article
- Review
- Reflective imaging of myelin integrity in the human and mouse central nervous systems.Frontiers in cellular neuroscience · 2024Article
- All-optical observation on activity-dependent nanoscale dynamics of myelinated axons.Neurophotonics · 2023Article
- Simulation of nerve fiber based on anti-resonant reflecting optical waveguide.Scientific reports · 2022Article
- Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy.Science advances · 2022Article
- Electromagnetic characteristics ofFrontiers in bioengineering and biotechnology · 2022Article
- Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging.Scientific reports · 2021Article
- LED array reflectance microscopy for scattering-based multi-contrast imaging.Optics letters · 2020Article
- Mechanical regulation of oligodendrocyte biology.Neuroscience letters · 2020Review
- Imaging spinal cord activity in behaving animals.Experimental neurology · 2019Review
- Label-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm.Nature communications · 2019Article
- Harmonic Generation Microscopy 2.0: New Tricks Empowering Intravital Imaging for Neuroscience.Frontiers in molecular biosciences · 2019Review
- Article
- Microsphere-based interferometric optical probe.Nature communications · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mammalian nervous system, myelin provides electrical insulation for the neural circuit by forming a highly organized, multilayered thin film around the axon fibers. Here, we investigate the spectral reflectance from this subcellular nanostructure and devise a new label-free technique based on a spectroscopic analysis of reflected light, enabling nanoscale imaging of myelinated axons in their natural living state. Using this technique, we demonstrate three-dimensional mapping of the axon diameter and sensing of dynamic changes in the substructure of myelin at nanoscale. We further reveal the prevalence of axon bulging in the brain cortex in vivo after mild compressive trauma. Our novel tool opens new avenues of investigation by creating unprecedented access to the nanostructural dynamics of live myelinated axons in health and disease.
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Registered trials
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