ArticleScientific reports2017
Differential effects on membrane permeability and viability of human keratinocyte cells undergoing very low intensity megasonic fields.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Differential Effects of Low-Intensity Pulsed Ultrasound and Antifungals onJournal of fungi (Basel, Switzerland) · 2026Article
- Computational and Cytotoxicity Evaluation of Phyllanthus Urinaria-Derived Compounds as Potential Anti-Cervical Cancer Agents via HPV-16 E6 Oncoprotein Inhibition.International journal of molecular sciences · 2026Article
- Low-intensity pulsed ultrasound induces multifaced alterations in chromosome segregation, cytoskeletal filaments and cell junctions.Scientific reports · 2025Article
- Ultrasound inhibits tumor growth and selectively eliminates malignant brain tumor in vivo.Bioengineering & translational medicine · 2024Article
- Musculoskeletal Biomaterials: Stimulated and Synergized with Low Intensity Pulsed Ultrasound.Journal of functional biomaterials · 2023Review
- Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles.International journal of molecular sciences · 2023Article
- Evaluation of supercritical COThe Science of the total environment · 2021Article
- The effect of low frequency and low intensity ultrasound combined with microbubbles on the sonoporation efficiency of MDA-MB-231 cells.Annals of translational medicine · 2020Article
- Ultrasound delivery of Surface Enhanced InfraRed Absorption active gold-nanoprobes into fibroblast cells: a biological study via Synchrotron-based InfraRed microanalysis at single cell level.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among different therapeutic applications of Ultrasound (US), transient membrane sonoporation (SP) - a temporary, non-lethal porosity, mechanically induced in cell membranes through US exposure - represents a compelling opportunity towards an efficient and safe drug delivery. Nevertheless, progresses in this field have been limited by an insufficient understanding of the potential cytotoxic effects of US related to the failure of the cellular repair and to the possible activation of inflammatory pathway. In this framework we studied the in vitro effects of very low-intensity US on a human keratinocyte cell line, which represents an ideal model system of skin protective barrier cells which are the first to be involved during medical US treatments. Bioeffects linked to US application at 1 MHz varying the exposure parameters were investigated by fluorescence microscopy and fluorescence activated cell sorting. Our results indicate that keratinocytes undergoing low US doses can uptake drug model molecules with size and efficiency which depend on exposure parameters. According to sub-cavitation SP models, we have identified the range of doses triggering transient membrane SP, actually with negligible biological damage. By increasing US doses we observed a reduced cells viability and an inflammatory gene overexpression enlightening novel healthy relevant strategies.
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