ArticleScientific reports2017
Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development.The Biochemical journal · 2022Review
- Adaptive differentiation promotes intestinal villus recovery.Developmental cell · 2022Article
- Phytate and Butyrate Differently Influence the Proliferation, Apoptosis and Survival Pathways in Human Cancer and Healthy Colonocytes.Nutrients · 2021Article
- Article
- Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration.JCI insight · 2020Article
- ERK Activity Imaging During Migration of Living Cells In Vitro and In Vivo.International journal of molecular sciences · 2019Review
- Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro.Cancer science · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal epithelial cells function as a barrier to protect our body from various agents; therefore, any damage to these cells must be immediately repaired. Several in vivo and vitro studies have shown the involvement of Erk (extracellular signal-regulated kinase) in the regeneration process; however, the spatial regulation of Erk related to tissue morphology has not been well documented. Using two-photon microscopy and mice carrying a Förster resonance energy transfer-based biosensor, we here monitored the Erk activity in the ileal epithelial cells of living mice. Forty-eight h after ischemia-induced injury, epithelial cells were observed as a monolayer covering the injured area. The Erk activity in these cells was higher than that in the epithelial cells at the surrounding crypts, and treatment with an epidermal growth factor receptor inhibitor cancelled the higher Erk activity. The resealing epithelial cells were not in the G
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