Evidence map›Paper›PMID 29184080›Full record

ArticleScientific reports2017

Factors affecting pitch discrimination performance in a cohort of extensively phenotyped healthy volunteers.

Lauren M Smith, Alex J Bartholomew, Lauren E Burnham, Barbara Tillmann, Elizabeth T Cirulli

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren M SmithUniversity Program in Genetics and Genomics, Duke University, Durham, NC, 27708, USA.
Alex J BartholomewDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27708, USA.
Lauren E BurnhamDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27708, USA.
Barbara TillmannLyon Neuroscience Research Center, Auditory Cognition and Psychoacoustics Team, CNRS-UMR 5292; INSERM, U1028, Lyon, F-69000, France.
Elizabeth T CirulliDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27708, USA. liz.cirulli@gmail.com.

Funding

Genetics Training Grant-Year 26T32GM007754 · NIGMS · DUKE UNIVERSITY · PI HAASE, STEVEN B · 1985 to 2019
$8.3M
Genetics of Normal Human Variation: Implications for DiseaseK01MH098126 · NIMH · DUKE UNIVERSITY · PI CIRULLI ROGERS, ELIZABETH TRILBY · 2013 to 2016
$555k
NIGMS NIH HHS T32 GM007754NIMH NIH HHS K01 MH098126
6 · The paper itself

Abstract

Despite efforts to characterize the different aspects of musical abilities in humans, many elements of this complex area remain unknown. Musical abilities are known to be associated with factors like intelligence, training, and sex, but a comprehensive evaluation of the simultaneous impact of multiple factors has not yet been performed. Here, we assessed 918 healthy volunteers for pitch discrimination abilities-their ability to tell two tones close in pitch apart. We identified the minimal threshold that the participants could detect, and we found that better performance was associated with higher intelligence, East Asian ancestry, male sex, younger age, formal music training-especially before age 6-and English as the native language. All these factors remained significant when controlling for the others, with general intelligence, musical training, and male sex having the biggest impacts. We also performed a small GWAS and gene-based collapsing analysis, identifying no significant associations. Future genetic studies of musical abilities should involve large sample sizes and an unbiased genome-wide approach, with the factors highlighted here included as important covariates.

Indexed as

Pitch DiscriminationPitch PerceptionAcoustic StimulationAdolescentAdultAgedAged, 80 and overCognitionFemaleGenetic Association StudiesHealthy VolunteersHumansMaleMiddle AgedMusicReproducibility of Results

Identifiers

PMID29184080
PMCPMC5705722

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.