ArticleScientific reports2017
Molecular architecture of potassium chloride co-transporter KCC2.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.Molecular genetics & genomic medicine · 2019Trial
- Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment.Channels (Austin, Tex.) · 2026Review
- KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury.Frontiers in molecular neuroscience · 2026Article
- KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q.Frontiers in molecular neuroscience · 2025Article
- Impact of aging on the GABAbioRxiv : the preprint server for biology · 2024Article
- The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2.Neurochemistry international · 2024Article
- Bidirectional Regulation of GABALife (Basel, Switzerland) · 2024Review
- Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library.Frontiers in molecular neuroscience · 2024Article
- KCC2 downregulation after sciatic nerve injury enhances motor function recovery.Scientific reports · 2023Article
- Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.Cell reports. Medicine · 2023Article
- Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.Journal of autism and developmental disorders · 2022Article
- Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.Brain : a journal of neurology · 2022Article
- Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology.Frontiers in physiology · 2022Review
- How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky withFrontiers in molecular neuroscience · 2022Article
- Potential Mechanisms Underlying Hypoxia-Induced Diabetes in a Rodent Model: Implications for COVID-19.Children (Basel, Switzerland) · 2021Article
- Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.Nature communications · 2021Article
- Cation-coupled chloride cotransporters: chemical insights and disease implications.Trends in chemistry · 2021Review
- Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 5 countries.
Morgane AgezCALIXAR, 60 avenue Rockefeller, 69008, Lyon, France.
Patrick SchultzDepartment of Integrated Structural Biology, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) INSERM, U964; CNRS/Strasbourg University, UMR7104 1, rue Laurent Fries, BP10142, 67404, Illkirch, France.
Igor MedinaINMED, INSERM Unité 901, Marseille, France.ORCID 0000-0001-6839-5414
David J BakerDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Matthew P BurnhamDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.
Ross A CardarelliAstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.ORCID 0000-0002-3692-6708
Leslie C ConwayAstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.
Kelly GarnierCALIXAR, 60 avenue Rockefeller, 69008, Lyon, France.
Stefan GeschwindnerDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Anders GunnarssonDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Eileen J McCallDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Alexandre FrechardDepartment of Integrated Structural Biology, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) INSERM, U964; CNRS/Strasbourg University, UMR7104 1, rue Laurent Fries, BP10142, 67404, Illkirch, France.
Stéphane AudebertAix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille Protéomique, Marseille, France.ORCID 0000-0002-9409-2588
Tarek Z DeebAstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, 02111, USA.
Nicholas J BrandonAstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.
Qi WangAstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.
Niek DekkerDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. niek.dekker@astrazeneca.com.
Anass JawhariCALIXAR, 60 avenue Rockefeller, 69008, Lyon, France. ajawhari@calixar.com.
Tufts University · USAstraZeneca (United Kingdom) · GBCentre National de la Recherche Scientifique · FRAstraZeneca (Sweden) · SEAstraZeneca (Japan) · JPInserm · FRPharnext (France) · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
KCC2 is a neuron specific K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.