ArticleScience signaling2017
Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.
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Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.Journal of lipid research · 2026Article
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- Inflammation and wound healing: a comprehensive overview of mechanisms, therapeutic strategies, and translational perspectives.Biomarker research · 2026Review
- Incorporation of Hydroxyeicosatetraenoic Acid Isomers into Macrophage Phospholipids Reveals Class-Specific Distribution.Biomolecules · 2026Article
- Allosteric properties of mammalian ALOX15 orthologs.The Journal of biological chemistry · 2026Review
- Lipidomic insights on abdominal aortic aneurysm and peripheral arterial disease.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Pro-Coagulant Lipids in Physiological Ratios Found in the Activated Platelet Membrane Do Not Impact Clot Structure or Fibrinolysis in Purified Assays.Journal of blood medicine · 2025Article
- Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.Frontiers in pharmacology · 2024Review
- Eating away cancer: the potential of diet and the microbiome for shaping immunotherapy outcome.Frontiers in immunology · 2024Review
- Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.Journal of lipid research · 2024Article
- LORA, Lipid Over-Representation Analysis Based on Structural Information.Analytical chemistry · 2023Article
- Software and Computational Tools for LC-MS-Based Epilipidomics: Challenges and Solutions.Analytical chemistry · 2023Review
- The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis.Open biology · 2022Review
- New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease.Biochemical Society transactions · 2022Review
- Relationship between lipoproteins, thrombosis, and atrial fibrillation.Cardiovascular research · 2022Review
- Dissecting lipid metabolism alterations in SARS-CoV-2.Progress in lipid research · 2021Review
- Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical.Bioscience reports · 2020Article
- The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles.PloS one · 2020Article
- The Biosynthesis of Enzymatically Oxidized Lipids.Frontiers in endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 7 institutions in 6 countries.
Sarah N LauderSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0003-2561-6277
Keith Allen-RedpathSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
David A SlatterSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0002-8197-4805
Maceler AldrovandiSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Anne O'ConnorSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Daniel FarewellDivision of Population Medicine, Cardiff University, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0002-8871-1653
Charles L PercySystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0002-0497-6495
Jessica E MolhoekDepartment of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.
Sirpa RannikkoDepartment of Medical Microbiology and Immunology, Research Unit of Biomedicine, Finland and Medical Research Center, University of Oulu, P.O. Box 5000, Oulu 90220, Finland.ORCID http://orcid.org/0000-0002-4018-8752
Victoria J TyrrellSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Salvatore FerlaWelsh School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0002-5918-9237
Ginger L MilneDivision of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37240, USA.ORCID http://orcid.org/0000-0003-3890-151X
Alastair W PooleSchool of Physiology, Pharmacy and Neuroscience, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK.ORCID http://orcid.org/0000-0002-0868-297X
Christopher P ThomasSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0001-5840-8613
Samya ObajiSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Philip R TaylorSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0003-0163-1421
Simon A JonesSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.ORCID http://orcid.org/0000-0001-7297-9711
Phillip G de GrootDepartment of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.
Rolf T UrbanusDepartment of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.ORCID http://orcid.org/0000-0002-1601-9393
Sohvi HörkköDepartment of Medical Microbiology and Immunology, Research Unit of Biomedicine, Finland and Medical Research Center, University of Oulu, P.O. Box 5000, Oulu 90220, Finland.ORCID http://orcid.org/0000-0003-2118-5270
Stefan UderhardtDepartment of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0002-2489-2109
Jochen AckermannDepartment of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
P Vince JenkinsInstitute of Molecular Medicine, St James's Hospital, Dublin, Ireland.
Andrea BrancaleWelsh School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF14 4XN, UK.
Gerhard KrönkeDepartment of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
Peter W CollinsSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. o-donnellvb@cardiff.ac.uk collinspw@cardiff.ac.uk.ORCID http://orcid.org/0000-0002-6410-1324
Valerie B O'DonnellSystems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. o-donnellvb@cardiff.ac.uk collinspw@cardiff.ac.uk.ORCID http://orcid.org/0000-0003-4089-8460
Cardiff University · GBUniversitätsklinikum Erlangen · DEUniversity Medical Center Utrecht · NLNordLab · FISt. James's Hospital · IEUniversity of Bristol · GBVanderbilt University Medical Center · US
Funding
Arthritis Research UK 20770British Heart Foundation FS/11/42/28753British Heart Foundation FS/16/20/32005British Heart Foundation RG/10/006/28299British Heart Foundation RG/12/11/29815British Heart Foundation RG/15/16/31758Wellcome Trust
Abstract
Blood coagulation functions as part of the innate immune system by preventing bacterial invasion, and it is critical to stopping blood loss (hemostasis). Coagulation involves the external membrane surface of activated platelets and leukocytes. Using lipidomic, genetic, biochemical, and mathematical modeling approaches, we found that enzymatically oxidized phospholipids (eoxPLs) generated by the activity of leukocyte or platelet lipoxygenases (LOXs) were required for normal hemostasis and promoted coagulation factor activities in a Ca
Indexed as
HemostasisPlatelet ActivationAdultAgedAnimalsAntiphospholipid Syndromebeta 2-Glycoprotein IBlood CoagulationBlood Coagulation FactorsCalciumCell MembraneCohort StudiesDisease Models, AnimalFemaleHumansHydroxyeicosatetraenoic Acidsbeta 2-Glycoprotein IBlood Coagulation FactorsCalciumHydroxyeicosatetraenoic AcidsLipoxygenasesPhospholipids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.