ArticleScience signaling2017
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
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Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
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Who cites it
47 citing papers in PubMed, 80 citations in OpenAlex.
- Mechanistic insights into Orai dynamics during pore opening.Channels (Austin, Tex.) · 2026Review
- Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026Article
- Establishment and evaluation of a prognostic model for sodium overload necrosis in acute myeloid leukemia.Translational cancer research · 2026Article
- Engineering of genetically encoded programmable calcium channel inhibitory binders.Nature communications · 2026Article
- Identifying 2PHDO as a SOCE Inhibitor from Chinese Herbal Extracts.Current pharmaceutical biotechnology · 2026Article
- Article
- Water in peripheral TM-interfaces of Orai1-channels triggers pore opening.Communications biology · 2024Article
- Bidirectional Allosteric Coupling between PIPInternational journal of molecular sciences · 2024Article
- Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1.Nature communications · 2023Article
- A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.eLife · 2023Article
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- The Role of Lipids in CRAC Channel Function.Biomolecules · 2022Review
- Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions.Cells · 2022Review
- STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.Frontiers in aging · 2022Review
- Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology.International journal of molecular sciences · 2021Review
- An open pore structure of the Orai channel, finally.Cell calcium · 2021Article
- TRPM4 in Cancer-A New Potential Drug Target.Biomolecules · 2021Review
- Engineering of a bona fide light-operated calcium channel.Nature communications · 2021Article
- The Orai Pore Opening Mechanism.International journal of molecular sciences · 2021Review
- Interrogating permeation and gating of Orai channels using chemical modification of cysteine residues.Methods in enzymology · 2021Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 5 countries.
Irene FrischaufInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.ORCID http://orcid.org/0000-0003-0661-2932
Monika LitviňukováInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.
Romana SchoberInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.
Vasilina ZayatsCenter for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic.
Barbora SvobodováInstitute for Biophysics, Medical University of Graz, Graz A-8010, Austria.
Daniel BonhenryCenter for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic.ORCID http://orcid.org/0000-0002-6069-7642
Victoria LunzInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.
Sabrina CappelloMolecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg August University Göttingen, Göttingen, Niedersachsen 37073, Germany.
Laura TociuCenter for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic.ORCID http://orcid.org/0000-0001-6218-5352
David RehaCenter for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic.
Amrutha StallingerInstitute for Molecular Biosciences, Karl-Franzens-University Graz, Graz A-8010, Austria.
Anna HochreiterInstitute for Experimental and Clinical Cell Therapy, Paracelsus Medical University, Salzburg A-5020, Austria.
Teresa PammerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.
Carmen ButoracInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.ORCID http://orcid.org/0000-0003-4581-4262
Martin MuikInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.ORCID http://orcid.org/0000-0003-2583-5939
Klaus GroschnerInstitute for Biophysics, Medical University of Graz, Graz A-8010, Austria.
Ivan BogeskiMolecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg August University Göttingen, Göttingen, Niedersachsen 37073, Germany.
Rüdiger H EttrichCenter for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic.ORCID http://orcid.org/0000-0001-8624-7706
Christoph RomaninInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz A-4020, Austria.ORCID http://orcid.org/0000-0003-3756-4136
Rainer SchindlInstitute for Biophysics, Medical University of Graz, Graz A-8010, Austria. rainer.schindl@medunigraz.at.ORCID http://orcid.org/0000-0003-0896-8887
Johannes Kepler University of Linz · ATMedical University of Graz · ATCzech Academy of Sciences · CZSewanee: The University of the South · USUniversity of Göttingen · DEParacelsus Medical University · ATUniversity of Graz · ATWarsaw University of Technology · PL
Funding
Austrian Science Fund FWF P 27263Austrian Science Fund FWF P 28498Austrian Science Fund FWF P 28701Austrian Science Fund FWF P 28872
Abstract
The channel Orai1 requires Ca
Indexed as
AnimalsArginineCalciumCell MembraneDrosophila melanogasterGenomicsHCT116 CellsHEK293 CellsHumansIon Channel GatingMolecular Dynamics SimulationMuscular DiseasesMutationNeoplasm ProteinsNeoplasmsORAI1 ProteinArginineCalciumNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.