Evidence map›Paper›PMID 29184017›Full record

ArticlemBio2017

Vaccination with Recombinant

Charles A Specht, Chrono K Lee, Haibin Huang, Maureen M Hester, Jianhua Liu, Bridget A Luckie, Melanie A Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham and 6 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026
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  3. A review of the current anti-New microbes and new infections · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Peripheral blood CD4The Journal of infection · 2025
    Article
  10. Evolutionary uniqueeLife · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. mBio · 2024
    Article
  15. Article
  16. Article
  17. Inbred Mouse Models inJournal of fungi (Basel, Switzerland) · 2024
    Review
  18. Review
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Charles A SpechtDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA charles.specht@umassmed.edu stuart.levitz@umassmed.edu.
Chrono K LeeDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Haibin HuangDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Maureen M HesterDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jianhua LiuDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Bridget A LuckieDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Melanie A Torres SantanaDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Zeynep MirzaProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Payam KhoshkenarProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Ambily AbrahamProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Zu T ShenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jennifer K LodgeDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ali AkalinDepartment of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jane HomanioGenetics LLC, Madison, Wisconsin, USA.
Gary R OstroffProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Stuart M LevitzDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA charles.specht@umassmed.edu stuart.levitz@umassmed.edu.
University of Massachusetts Chan Medical School · USioGenetics (United States) · USWashington University in St. Louis · US

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
ROLE OF MACROPHAGES IN CRYPTOCOCCAL INFECTIONSR01AI025780 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 1987 to 2019
$7.1M
Chitosan in CryptococcusR01AI072195 · NIAID · WASHINGTON UNIVERSITY · PI LODGE, JENNIFER K. · 2008 to 2018
$3.5M
Glucan Particles as a Vaccine Platform for Protective ImmunityR01AI102618 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 2013 to 2016
$2.1M
Interactions of pDCs with AspergilusR01HL112671 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 2013 to 2016
$1.7M
NHLBI NIH HHS R01 HL112671NIAID NIH HHS R01 AI025780NIAID NIH HHS R01 AI072195NIAID NIH HHS R01 AI102618NIAID NIH HHS R01 AI125045
6 · The paper itself

Abstract

Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated with crude

Indexed as

AnimalsAntigens, FungalCloning, MolecularCryptococcosisCryptococcus gattiiCryptococcus neoformansDisease Models, AnimalDrug CarriersEscherichia coliFungal ProteinsFungal VaccinesGene ExpressionGlucansLungLung Diseases, FungalMiceAntigens, FungalDrug CarriersFungal ProteinsFungal VaccinesGlucansRecombinant ProteinsVaccines, SubunitVaccines, SyntheticbioinformaticsCryptococcusglucansimmunizationmajor histocompatibility complex

Identifiers

PMID29184017
PMCPMC5705919
OpenAlexW2768821520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.