ArticleDevelopment (Cambridge, England)2017
Anisotropic shear stress patterns predict the orientation of convergent tissue movements in the embryonic heart.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- A Continuum of Atrial Peristalsis Initiates the Bicuspid to Quadricuspid Valve Transition.bioRxiv : the preprint server for biology · 2026Article
- Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis.Science advances · 2026Article
- CellMet: Extracting 3D shape and topology metrics from confluent cells within tissues.PLoS computational biology · 2025Article
- Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature.Drug delivery and translational research · 2024Article
- Article
- Response of cells and tissues to shear stress.Journal of cell science · 2023Review
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids.Communications biology · 2023Article
- TheFrontiers in physiology · 2023Article
- Pulsations and flows in tissues as two collective dynamics with simple cellular rules.iScience · 2022Article
- Engineering multiscale structural orders for high-fidelity embryoids and organoids.Cell stem cell · 2022Review
- Endocardial Regulation of Cardiac Development.Journal of cardiovascular development and disease · 2022Review
- Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish.Journal of cardiovascular development and disease · 2022Article
- Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling.PLoS biology · 2022Article
- Shear type and magnitude affect aortic valve endothelial cell morphology, orientation, and differentiation.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Fluid mechanics of the left atrial ligation chick embryonic model of hypoplastic left heart syndrome.Biomechanics and modeling in mechanobiology · 2021Article
- The roles and activation of endocardial Notch signaling in heart regeneration.Cell regeneration (London, England) · 2021Review
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- Mechanics of Development.Developmental cell · 2021Review
- Mechanisms of heart valve development and disease.Development (Cambridge, England) · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial contractility and blood flow provide essential mechanical cues for the morphogenesis of the heart. In general, endothelial cells change their migratory behavior in response to shear stress patterns, according to flow directionality. Here, we assessed the impact of shear stress patterns and flow directionality on the behavior of endocardial cells, the specialized endothelial cells of the heart. At the early stages of zebrafish heart valve formation, we show that endocardial cells are converging to the valve-forming area and that this behavior depends upon mechanical forces. Quantitative live imaging and mathematical modeling allow us to correlate this tissue convergence with the underlying flow forces. We predict that tissue convergence is associated with the direction of the mean wall shear stress and of the gradient of harmonic phase-averaged shear stresses, which surprisingly do not match the overall direction of the flow. This contrasts with the usual role of flow directionality in vascular development and suggests that the full spatial and temporal complexity of the wall shear stress should be taken into account when studying endothelial cell responses to flow
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.