Evidence map›Paper›PMID 29183910›Full record

ArticleDiabetes care2018

Predictors of Quality of Life and Other Patient-Reported Outcomes in the PANORAMA Multinational Study of People With Type 2 Diabetes.

Clare Bradley, Eveline Eschwège, Pedro de Pablos-Velasco, Klaus G Parhofer, Dominique Simon, Hans Vandenberghe, Linda Gönder-Frederick

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

  1. Evaluating the Use of Anxiety Patient-Reported Outcome Measures (PROMs) in Dementia Clinical Trials: A Systematic Review.Health expectations : an international journal of public participation in health care and health policy · 2026
    Pooled it
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  8. An Assessment of Diabetes-Dependent Quality of Life in Polish Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
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  9. Tight and early HbAFrontiers in public health · 2025
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  13. Improved Glycaemic and Weight Management Are Associated with Better Quality of Life in People with Type 2 Diabetes Treated with Tirzepatide.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Clare BradleyHealth Psychology Research Unit, Royal Holloway, University of London, Egham, U.K. c.bradley@rhul.ac.uk.ORCID 0000-0002-4079-0364
Eveline EschwègeINSERM, Paris, France.
Pedro de Pablos-VelascoDr. Negrin Hospital, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Klaus G ParhoferMedical Department 4, Grosshadern, Klinikum der Universität München, Munich, Germany.
Dominique SimonInstitute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Paris, France.
Hans VandenbergheAstraZeneca, Uccle, Belgium.
Linda Gönder-FrederickUniversity of Virginia Health System, Charlottesville, VA.
Inserm · FRLMU Klinikum · DERoyal Holloway University of London · GBSorbonne Université · FRUniversidad de Las Palmas de Gran Canaria · ESUniversity of Virginia Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND

methodsPatients were randomly or consecutively selected from primary/secondary care. PROMs included the Audit of Diabetes-Dependent Quality of Life (ADDQoL) (generic QoL item and average weighted impact [AWI] scores), Diabetes Treatment Satisfaction Questionnaire (DTSQ) (patient- and physician-completed), Hypoglycemia Fear Survey-II worry subscale, and the EuroQoL-5 Dimension visual analog scale (EQ-VAS) measuring patient-reported health. Multivariable linear regression analyses determined predictors of each PROM including patient characteristics, physician-reported adherence, complications, and glycosylated hemoglobin.

resultsIn 5,813 patients, mean PROM scores indicated that generic QoL approximated "good" (0.93); perceived impact of diabetes on QoL was negative (AWI -1.69). Treatment satisfaction exceeded physicians' estimates (patient-reported: 29.76; physician-estimated: 27.75), but so did patients' perceived frequency of hypo-/hyperglycemia. Worry about hypoglycemia (13.27) was apparent. Intensifying treatments to three oral agents or insulin regimens predicted worse QoL (AWI

conclusionsPredictors for different PROMs differed markedly and provided insights for understanding and improving these important outcomes. Intensive treatment regimens had significant negative associations with all PROMs, except the EQ-VAS health status measure. The findings demonstrate the importance of measuring QoL alongside health status and other patient-reported outcomes when evaluating diabetes treatments with a view to protecting QoL and facilitating adherence and long-term glycemic control.

Indexed as

Quality of LifeAdultAgedAnxietyBlood GlucoseCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansHypoglycemiaInternationalityMaleMiddle AgedPatient Reported Outcome MeasuresSelf ReportBlood GlucoseGlycated Hemoglobin

Identifiers

PMID29183910
OpenAlexW2770705944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.