Evidence map›Paper›PMID 29183835›Full record

ArticleEuropean journal of pharmacology2018

Antinociceptive effects of mixtures of mu opioid receptor agonists and cannabinoid receptor agonists in rats: Impact of drug and fixed-dose ratio.

David R Maguire, Charles P France

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Enhancement of Opioid Antinociception by Nicotinic Ligands.The Journal of pharmacology and experimental therapeutics · 2021
    Article
  9. Article
  10. Article
  11. Enhancement of Opioid Antinociception by Nicotine.The Journal of pharmacology and experimental therapeutics · 2019
    Article
  12. Article
  13. Article
  14. Cannabis-based medicines and the perioperative physician.Perioperative medicine (London, England) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David R MaguireDepartments of Pharmacology, the University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX 78229, USA; Addiction Research, Treatment & Training Center of Excellence, the University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX 78229, USA.
Charles P FranceDepartments of Pharmacology, the University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX 78229, USA; Departments of Psychiatry, the University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX 78229, USA; Addiction Research, Treatment & Training Center of Excellence, the University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX 78229, USA. Electronic address: france@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US

Funding

Behavioral Pharmacology of Drug DependenceK05DA017918 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRANCE, CHARLES P · 2005 to 2014
$1.2M
NIDA NIH HHS K05 DA017918
6 · The paper itself

Abstract

Pain is a significant clinical problem, and there is a need for effective pharmacotherapies with fewer adverse effects than currently available drugs (e.g., mu opioid receptor agonists). Cannabinoid receptor agonists enhance the antinociceptive effects of mu opioid receptor agonists, but it remains unclear which drugs and in what proportion will yield the most effective and safest treatments. The antinociceptive effects of the mu opioid receptor agonists etorphine and morphine alone and in combination with the cannabinoid receptor agonists Δ

Indexed as

AnalgesicsAnimalsCannabinoid Receptor AgonistsCyclohexanolsDose-Response Relationship, DrugDronabinolDrug InteractionsMaleRatsRats, Sprague-DawleyReceptors, Opioid, mu3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolAnalgesicsCannabinoid Receptor AgonistsCyclohexanolsDronabinolReceptors, Opioid, muAntinociceptionCannabinoid receptor agonistDrug-drug interactionsmu opioid receptor agonistRatsThermal nociception

Identifiers

PMID29183835
PMCPMC5766417
OpenAlexW2770367915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.