Evidence map›Paper›PMID 29183834›Full record

ArticleAnalytical biochemistry2018

Contact lens to measure individual ion concentrations in tears and applications to dry eye disease.

Ramachandram Badugu, Bennie H Jeng, E Albert Reece, Joseph R Lakowicz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ramachandram BaduguCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 W. Lombard Street, Baltimore, MD 21201, USA. Electronic address: rbadugu@umaryland.edu.
Bennie H JengDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W. Redwood Street, Suite 420, Baltimore, MD 21201, USA.
E Albert ReeceDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD 21201, USA; Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD 21201, USA.
Joseph R LakowiczCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 W. Lombard Street, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · US

Funding

Plasmon-Controlled Fluorescence and Cardiac MarkersR01EB006521 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2007 to 2015
$2.7M
Coupled Emission Microscopy for the BiosciencesR01GM125976 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2018 to 2021
$1.8M
Diffusion-Enhanced Lanthanide Nanoparticle FRET AssaysR21GM107986 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2014 to 2016
$568k
Bioaffinity Assays Using UV One-Dimensional Photonic Crystals (1DPC)R21EB018959 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2015 to 2016
$420k
Multi-User Time-Resolved Fluorescence SpectrometerS10OD019975 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2015 to 2015
$243k
NIBIB NIH HHS R01 EB006521NIBIB NIH HHS R21 EB018959NIGMS NIH HHS R01 GM125976NIGMS NIH HHS R21 GM107986NIH HHS S10 OD019975
6 · The paper itself

Abstract

Dry eye disease (DED) affects millions of individuals in the United States and worldwide, and the incidence is increasing with an aging population. There is widespread agreement that the measurement of total tear osmolarity is the most reliable test, but this procedure provides only the total ionic strength and does not provide the concentration of each ionic species in tears. Here, we describe an approach to determine the individual ion concentrations in tears using modern silicone hydrogel (SiHG) contact lenses. We made pH (or H

Indexed as

Contact LensesChloridesDry Eye SyndromesHumansHydrogel, Polyethylene Glycol DimethacrylateHydrogen-Ion ConcentrationHydroxidesIonsSiliconesTearsChloridesHydrogel, Polyethylene Glycol Dimethacrylatehydroxide ionHydroxidesIonsSiliconesChloride ionContact lensDry eye diseaseElectrolytesFluorescence sensorsHydrogelsHydronium ionSilicone hydrogels

Identifiers

PMID29183834
PMCPMC5817005
OpenAlexW2770603049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.