ArticleNeuroscience2018
Chronic Intranasal Oxytocin has Dose-dependent Effects on Central Oxytocin and Vasopressin Systems in Prairie Voles (Microtus ochrogaster).
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.Frontiers in behavioral neuroscience · 2026Article
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Divergent neural nodes are species- and hormone-dependent in the brood parasitic brain.Genes, brain, and behavior · 2024Article
- Oxytocin and its links through scientific lineage.Comprehensive psychoneuroendocrinology · 2024Article
- Conserved and differing functions of the endocrine system across different social systems - oxytocin as a case study.Frontiers in endocrinology · 2024Review
- Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023Review
- Developmental exposure to intranasal vasopressin impacts adult prairie vole spatial memory.Psychoneuroendocrinology · 2022Article
- Effects of Chronic and Acute Intranasal Oxytocin Treatments on Temporary Social Separation in Adult Titi Monkeys (Frontiers in behavioral neuroscience · 2022Article
- Oxytocin in Women's Health and Disease.Frontiers in endocrinology · 2022Review
- Intranasal oxytocin drives coordinated social approach.Scientific reports · 2021Article
- Validation of a commercial enzyme immunoassay to assess urinary oxytocin in humans.Endocrine connections · 2021Article
- Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research.Molecular psychiatry · 2021Review
- Article
- Effects of chronic intranasal oxytocin on behavior and cerebral glucose uptake in juvenile titi monkeys.Psychoneuroendocrinology · 2020Article
- Developmental Fluoxetine Exposure Alters Behavior and Neuropeptide Receptors in the Prairie Vole.Frontiers in behavioral neuroscience · 2020Article
- Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin.Hormones and behavior · 2019Article
- The Impact of Early Postnatal and Juvenile Social Environments on the Effects of Chronic Intranasal Oxytocin in the Prairie Vole.Frontiers in behavioral neuroscience · 2019Article
- Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients.Frontiers in psychiatry · 2019Article
- Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Oxytocin (Oxt) is a neuropeptide with many functions, including modulation of social behavior(s) and anxiety. Due to its notable pro-social effects, it has been proposed as a treatment in the management of neuropsychiatric disorders, such as autism spectrum disorder (ASD), schizophrenia, and social anxiety; however, effects of long-term daily treatment are still being explored. Previously, we have shown that in male prairie voles (Microtus ochrogaster) exposure to Oxt during the peri-adolescent period impaired adult pair bonding in a dose-dependent fashion. In females, the medium dose used (0.8 IU/kg) appeared to facilitate pair bonding, and the low and medium doses were associated with fewer lines crossed in the open field. In this study, we examined central receptor binding and immunoreactive (IR) protein for Oxt and vasopressin (Avp), a closely related peptide. Voles were treated with saline vehicle, or one of three doses of Oxt (0.08, 0.8, 8.0 IU/kg) for three weeks from postnatal days 21 to 42, and euthanized as adults. We used autoradiography to examine Oxt and Avp receptor binding and immunohistochemistry to examine Oxt and Avp - IR cells in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. Females that received the medium dose of Oxt had higher Oxt receptor binding in the nucleus accumbens shell (NAS), while males that received the medium dose had lower Avp-IR cells in the PVN. In summary, we found sex-specific effects of long-term exposure to intranasal Oxt on the Oxt and Avp systems at the weight-adjusted dose currently being used in clinical trials in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.