Evidence map›Paper›PMID 29183735›Full record

ArticleVaccine2018

Meningococcal carriage among a university student population - United States, 2015.

Lucy Breakwell, Melissa Whaley, Unab I Khan, Utpala Bandy, Nicole Alexander-Scott, Lynn Dupont, Cindy Vanner, How-Yi Chang, Jeni T Vuong, Stacey Martin and 3 more

Abstract read
In one paragraph

Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Meningococcal Vaccination: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2020
    Guideline
  3. Pooled it
  4. Pooled it
  5. Carriage prevalence of Neisseria meningitidis in the Americas in the 21st century: a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Pooled it
  6. Review
  7. Article
  8. Article
  9. Meningococcal carriage in children and young adults: a cross-sectional and longitudinal study, Iceland, 2019 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  10. Article
  11. Article
  12. Evaluation of pharyngeal carriage ofNew microbes and new infections · 2022
    Article
  13. Article
  14. Article
  15. Meningococcal disease and vaccination in college students.Human vaccines & immunotherapeutics · 2021
    Review
  16. Article
  17. Article
  18. Human Immunodeficiency Virus Infection Is Associated With Increased Meningococcal Carriage Acquisition Among First-year Students in 2 South African Universities.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  19. Article
  20. [Journal of preventive medicine and hygiene · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucy BreakwellMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States; Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30329, United States.
Melissa WhaleyMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States.
Unab I KhanUniversity Health Services, Brown University, 13 Brown Street, Providence, RI 02906, United States.
Utpala BandyRhode Island Department of Health, 3 Capitol Hill, Providence, RI 02908, United States.
Nicole Alexander-ScottRhode Island Department of Health, 3 Capitol Hill, Providence, RI 02908, United States.
Lynn DupontUniversity Health Services, Brown University, 13 Brown Street, Providence, RI 02906, United States.
Cindy VannerRhode Island Department of Health, 3 Capitol Hill, Providence, RI 02908, United States.
How-Yi ChangMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States.
Jeni T VuongMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States.
Stacey MartinMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States.
Jessica R MacNeilMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States.
Xin WangMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States.
Sarah A MeyerMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, United States. Electronic address: smeyer@cdc.gov.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectivesSeveral outbreaks of serogroup B meningococcal disease have occurred among university students in recent years. In the setting of high coverage of the quadrivalent meningococcal conjugate vaccine and prior to widespread use of serogroup B meningococcal vaccines among adolescents, we conducted surveys to characterize the prevalence and molecular characteristics of meningococcal carriage among university students.

methodsTwo cross-sectional oropharyngeal carriage surveys were conducted among undergraduates at a Rhode Island university. Isolates were characterized using slide agglutination, real-time polymerase chain reaction (rt-PCR), and whole genome sequencing. Adjusted prevalence ratios and 95% confidence intervals were calculated using Poisson regression to determine risk factors for carriage.

resultsA total of 1837 oropharyngeal specimens were obtained from 1478 unique participants. Overall carriage prevalence was 12.7-14.6% during the two survey rounds, with 1.8-2.6% for capsular genotype B, 0.9-1.0% for capsular genotypes C, W, or Y, and 9.9-10.8% for nongroupable strains by rt-PCR. Meningococcal carriage was associated with being male, smoking, party or club attendance, recent antibiotic use (inverse correlation), and recent respiratory infections.

conclusionsIn this university setting, the majority of meningococcal carriage was due to nongroupable strains, followed by serogroup B. Further evaluation is needed to understand the dynamics of serogroup B carriage and disease among university students.

Indexed as

StudentsAntigens, BacterialCarrier StateCross-Sectional StudiesDisease OutbreaksFemaleGenotypeHumansMaleMeningococcal InfectionsMeningococcal VaccinesMolecular TypingNeisseria meningitidisNeisseria meningitidis, Serogroup BOropharynxPoisson DistributionAntigens, BacterialMeningococcal VaccinesCarriageMeningococcal diseaseMeningococcal infectionsMeningococcal vaccinesNeisseria meningitidis

Identifiers

PMID29183735
PMCPMC5737556

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.