Evidence map›Paper›PMID 29183717›Full record

ReviewTrends in parasitology2018

Using Wolbachia for Dengue Control: Insights from Modelling.

Ilaria Dorigatti, Clare McCormack, Gemma Nedjati-Gilani, Neil M Ferguson

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Wolbachia-carrying Aedes mosquitoes for preventing dengue infection.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Larval diet-mediated morphological trait andFrontiers in insect science · 2026
    Article
  6. Detection of novelFrontiers in microbiology · 2026
    Article
  7. Article
  8. Review
  9. Long-Term Durability and Public Health Impact of City-WideTropical medicine and infectious disease · 2025
    Article
  10. Article
  11. Review
  12. Dengue Virus Infection: Immune Response and Therapeutic Targets.The American journal of tropical medicine and hygiene · 2025
    Review
  13. Life table variations inFrontiers in insect science · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Viruses · 2024
    Review
  18. Article
  19. Article
  20. China's public health initiatives for climate change adaptation.The Lancet regional health. Western Pacific · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilaria DorigattiMRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK; These authors made equal contributions.
Clare McCormackMRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK; These authors made equal contributions.
Gemma Nedjati-GilaniMRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK; These authors made equal contributions.
Neil M FergusonMRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK. Electronic address: neil.ferguson@imperial.ac.uk.

Funding

Models for synthesising molecular, clinical and epidemiological data, and translaU01GM110721 · NIGMS · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI CAUCHEMEZ, SIMON, FERGUSON, NEIL MORRIS · 2014 to 2018
$1.9M
Medical Research Council MR/R015600/1NIGMS NIH HHS U01 GM110721
6 · The paper itself

Abstract

Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics. Traditional insecticide-based vector-control programmes have limited effectiveness, and the one licensed vaccine has a complex and imperfect efficacy profile. Strains of the bacterium Wolbachia, deliberately introduced into Aedes aegyptimosquitoes, have been shown to be able to spread to high frequencies in mosquito populations in release trials, and mosquitoes infected with these strains show markedly reduced vector competence. Thus, Wolbachia represents an exciting potential new form of biocontrol for arboviral diseases, including dengue. Here, we review how mathematical models give insight into the dynamics of the spread of Wolbachia, the potential impact of Wolbachia on dengue transmission, and we discuss the remaining challenges in evaluation and development.

Indexed as

Biological Control AgentsModels, TheoreticalAedesAnimalsDengueDengue VirusInsect VectorsWolbachiaBiological Control Agents

Identifiers

PMID29183717
PMCPMC5807169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.