ArticlePsychological medicine2018
Genetic risk of major depressive disorder: the moderating and mediating effects of neuroticism and psychological resilience on clinical and self-reported depression.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Psychological resilience and mood disorders: a systematic review and meta-analysis.Trends in psychiatry and psychotherapy · 2024Pooled it
- Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.Molecular psychiatry · 2021Pooled it
- Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores.JCPP advances · 2026Article
- Depression detectives: piloting a methodology for online co-produced research.Research involvement and engagement · 2026Article
- The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.Behavior genetics · 2026Article
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- Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS.Development and psychopathology · 2025Article
- The prospective association of adolescent loneliness and low resilience with anxiety and depression in young adulthood: The HUNT study.Social psychiatry and psychiatric epidemiology · 2025Article
- Mediation Effect of Resilience Between Social Support and Depression Symptoms in Patients With Strabismus: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- Influences of sex and gender on the associations between risk and protective factors, brain, and behavior.Biology of sex differences · 2024Review
- No association between serotonin 4 receptor brain binding and personality trait Neuroticism - A positron emission tomography study in depressed patients and healthy individuals.Neuroscience applied · 2024Article
- Resilience Phenotypes and Psychological Functioning among Individuals with Opioid Use Disorder.Substance use & misuse · 2024Article
- Article
- Emotional Vulnerability in Adolescents (EVA) Longitudinal Study: Identifying individual differences in symptoms of adolescent depression and anxiety and their biopsychosocial mechanisms based on demographic and mental health characteristics.Wellcome open research · 2024Article
- Neural Mechanisms Underlying the Impact of Psychological Resilience on Psychosocial Stress Responses.Depression and anxiety · 2024Article
- Optimal Physical Activity Is Associated with the Reduction of Depressive Symptoms via Neuroticism and Resilience.Healthcare (Basel, Switzerland) · 2023Article
- Psychometric properties of the 10-item Connor-Davidson Resilience Scale in Chinese military personnel.Frontiers in psychology · 2023Article
- Associations Between Personality Traits, Perceived Stress and Depressive Symptoms in Gynecological Cancer Patients Characterized by the Short and Long Allele Variant of the 5-HTTLPR Genotype: Preliminary Results.Clinical neuropsychiatry · 2022Article
- The Mediation Effect of Coping Strategies between Personality and Blood Pressure in Pregnancy Complicated by Hypertension.Healthcare (Basel, Switzerland) · 2022Article
- College students' screening early warning factors in identification of suicide risk.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPolygenic risk scores (PRS) for depression correlate with depression status and chronicity, and provide causal anchors to identify depressive mechanisms. Neuroticism is phenotypically and genetically positively associated with depression, whereas psychological resilience demonstrates negative phenotypic associations. Whether increased neuroticism and reduced resilience are downstream mediators of genetic risk for depression, and whether they contribute independently to risk remains unknown.
methodsModerating and mediating relationships between depression PRS, neuroticism, resilience and both clinical and self-reported depression were examined in a large, population-based cohort, Generation Scotland: Scottish Family Health Study (N = 4166), using linear regression and structural equation modelling. Neuroticism and resilience were measured by the Eysenck Personality Scale Short Form Revised and the Brief Resilience Scale, respectively.
resultsPRS for depression was associated with increased likelihood of self-reported and clinical depression. No interaction was found between PRS and neuroticism, or between PRS and resilience. Neuroticism was associated with increased likelihood of self-reported and clinical depression, whereas resilience was associated with reduced risk. Structural equation modelling suggested the association between PRS and self-reported and clinical depression was mediated by neuroticism (43-57%), while resilience mediated the association in the opposite direction (37-40%). For both self-reported and clinical diagnoses, the genetic risk for depression was independently mediated by neuroticism and resilience.
conclusionsFindings suggest polygenic risk for depression increases vulnerability for self-reported and clinical depression through independent effects on increased neuroticism and reduced psychological resilience. In addition, two partially independent mechanisms - neuroticism and resilience - may form part of the pathway of vulnerability to depression.
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