ArticleBMC complementary and alternative medicine2017
Cytotoxic activity of NN-32 toxin from Indian spectacled cobra venom on human breast cancer cell lines.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Toxin-Derived Peptides as Potentials Weapons Against Cancer.Pharmaceutics · 2026Review
- Antiproliferative Effects ofToxins · 2024Article
- Venom-derived peptides for breaking through the glass ceiling of drug development.Frontiers in chemistry · 2024Review
- Proteome of monocled cobra (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
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- Reptiles as Promising Sources of Medicinal Natural Products for Cancer Therapeutic Drugs.Pharmaceutics · 2022Review
- [Agkistrodon halys venom antitumor component-I inhibits vasculogenic mimicry in triple-negative breast cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Comparative Snake Venom Analysis for Facilitating Wildlife Forensics: A Pilot Study.Journal of analytical methods in chemistry · 2022Article
- Anticancer potential of nanogold conjugated toxin GNP-NN-32 fromThe journal of venomous animals and toxins including tropical diseases · 2020Article
- Cytotoxicity of Snake Venoms and Cytotoxins From Two Southeast Asian Cobras (Frontiers in molecular biosciences · 2020Article
- Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro.International journal of molecular medicine · 2019Article
- Phospholipase APeerJ · 2019Article
- Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide.Journal of cellular and molecular medicine · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBreast cancer is the most common cancer which causes significant morbidity and mortality among women worldwide. Lack of medical facilities for early detection, therapeutic strategies for treatment and side effects due to pharmacological compounds have encompassed the need for new therapies mostly from natural sources. A lot of components have been identified from different snake venoms as therapeutic agents. A group of polypeptides (60-70 amino acid residues) called cytotoxins or cardiotoxins present in an elapid family of snakes have a wide variety of pharmaceutical actions and have the tendency to damage a wide variety of cells including cancerous cells. The aim of the present study was to evaluate the cytotoxic effect of NN-32 protein toxin purified from Indian Spectacled Cobra venom against human breast cancer cell lines (MCF-7 and MDA-MB-231).
methodsThe NN-32 toxin was purified by ion exchange chromatography and further by RP-HPLC. The potential anticancer effects of the NN-32 toxin on MCF-7 and MDA-MB-231 cells were evaluated using MTT, anti-proliferation, neutral red (NR) uptake and Lactate Dehydrogenase (LDH) release assay.
resultsThe ion exchange chromatography showed various peaks among fraction no. 35 showing cytotoxic activity and this fraction showed a single peak with retention time 3.6 mins by HPLC using C18 column. The NN-32 toxin induced cytotoxicity in MCF-7 and MDA-MB-231 cells with the IC
conclusionThe purified toxin NN-32 from Naja naja venom showed cytotoxic activity against MCF-7 (ER+) and MDA-MB-231(ER-) cells in both dose dependent and time dependent manner.
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