Evidence map›Paper›PMID 29183324›Full record

Trial reportNutrition journal2017

Novel essential amino acid supplements enriched with L-leucine facilitate increased protein and energy intakes in older women: a randomised controlled trial.

Theocharis Ispoglou, Kevin Deighton, Roderick Fgj King, Helen White, Matthew Lees

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07754760 (Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07754760 nacompletednot on this mapstarted 2022, after this paper: background citation

Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults: a Randomised Crossover Trial

TypeinterventionalSponsorLeeds Beckett UniversityRan2022 to 2022Enrolled10ConditionsOlder Adults Without Any Specific Clinical ConditionArmsEssential amino acid supplement, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Article
  9. Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy.International journal of environmental research and public health · 2021
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Theocharis IspoglouCarnegie School of Sport, Leeds Beckett University, Headingley Campus, Fairfax Hall, Leeds, LS6 3QS, UK. t.ispoglou@leedsbeckett.ac.uk.ORCID http://orcid.org/0000-0002-7608-6512
Kevin DeightonCarnegie School of Sport, Leeds Beckett University, Headingley Campus, Fairfax Hall, Leeds, LS6 3QS, UK.
Roderick Fgj KingCarnegie School of Sport, Leeds Beckett University, Headingley Campus, Fairfax Hall, Leeds, LS6 3QS, UK.
Helen WhiteSchool of Applied and Clinical Sciences, Leeds Beckett University, CL413 Calverley Building Civic Quarter, Leeds, LS1 3HE, UK.
Matthew LeesCarnegie School of Sport, Leeds Beckett University, Headingley Campus, Fairfax Hall, Leeds, LS6 3QS, UK.
Leeds Beckett University · GB

Funding

Higher Education Funding Council for England HEIF funding
6 · The paper itself

Abstract

backgroundInadequate protein intake (PI), containing a sub-optimal source of essential amino acids (EAAs), and reduced appetite are contributing factors to age-related sarcopenia. The satiating effects of dietary protein per se may negatively affect energy intake (EI), thus there is a need to explore alternative strategies to facilitate PI without compromising appetite and subsequent EI.

methodsOlder women completed two experiments (EXP1 and EXP2) where they consumed either a Bar (565 kJ), a Gel (477 kJ), both rich in EAAs (7.5 g, 40% L-leucine), or nothing (Control). In EXP1, participants (n = 10, 68 ± 5 years, mean ± SD) consumed Bar, Gel or Control with appetite sensations and appetite-related hormonal responses monitored for one hour, followed by consumption of an ad libitum breakfast (ALB). In EXP2, participants (n = 11, 69 ± 5 years) ingested Bar, Gel or Control alongside an ALB.

resultsIn EXP1, EI at ALB was not different (P = 0.674) between conditions (1179 ± 566, 1254 ± 511, 1206 ± 550 kJ for the Control, Bar, and Gel respectively). However, total EI was significantly higher in the Bar and Gel compared to the Control after accounting for the energy content of the supplements (P < 0.0005). Analysis revealed significantly higher appetite Area under the Curve (AUC) (P < 0.007), a tendency for higher acylated ghrelin AUC (P = 0.087), and significantly lower pancreatic polypeptide AUC (P = 0.02) in the Control compared with the Bar and Gel. In EXP2, EI at ALB was significantly higher (P = 0.028) in the Control (1282 ± 513 kJ) compared to the Bar (1026 ± 565 kJ) and Gel (1064 ± 495 kJ). However, total EI was significantly higher in the Bar and Gel after accounting for the energy content of the supplements (P < 0.007).

conclusionsSupplementation with either the Bar or Gel increased total energy intake whether consumed one hour before or during breakfast. This may represent an effective nutritional means for addressing protein and total energy deficiencies in older women.

trial registrationClinical trial register: retrospectively registered, ISRCTN12977929 on.

Indexed as

Dietary SupplementsEnergy IntakeAgedAged, 80 and overAmino Acids, EssentialAnthropometryAppetiteBreakfastC-Reactive ProteinCross-Over StudiesDietary ProteinsFemaleGhrelinHumansLeucineMiddle AgedAmino Acids, EssentialC-Reactive ProteinDietary ProteinsGhrelinLeucinePancreatic PolypeptidePeptide YYAppetiteEnergyHormonesL-leucineProteinSarcopenia

Identifiers

PMID29183324
PMCPMC5704600
OpenAlexW2768442047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.