Evidence map›Paper›PMID 29183288›Full record

ArticleBMC pulmonary medicine2017

Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.

Roy H E Cloots, Selvakumari Sankaranarayanan, Matthew E Poynter, Els Terwindt, Paul van Dijk, Wouter H Lamers, S Eleonore Köhler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.The Journal of allergy and clinical immunology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Effect ofJournal of asthma and allergy · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Arginase 1 (Journal of clinical medicine · 2021
    Article
  17. Arginine Therapy for Lung Diseases.Frontiers in pharmacology · 2021
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Roy H E ClootsDepartment of Anatomy & Embryology and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Selvakumari SankaranarayananDepartment of Anatomy & Embryology and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Matthew E PoynterDivision of Pulmonary Disease and Critical Care, Department of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA.
Els TerwindtDepartment of Anatomy & Embryology and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Paul van DijkDepartment of Anatomy & Embryology and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Wouter H LamersDepartment of Anatomy & Embryology and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
S Eleonore KöhlerDepartment of Anatomy & Embryology and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands. leo.koehler@maastrichtuniversity.nl.
Maastricht University · NLAcademic Medical Center · NLUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background(Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis. We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) and lung inflammation in female mice with ovalbumin (OVA)-induced allergic asthma.

methodsArg1 was ablated in the lung by crossing Arg1

resultsArg1 ablation had no influence on the development of OVA-induced AHR, but attenuated OVA-induced increases in expression of Arg2 and Nos2, Slc7a1, Slc7a2, and Slc7a7 (arginine transporters), Il4, Il5 and Il13 (T

conclusionComplete ablation of Arg1 in the lung affects mRNA abundance of arginine-transporting and -metabolizing genes, and pro-inflammatory genes, but not methacholine responsiveness or accumulation of inflammatory cells.

Indexed as

Airway ResistanceAmino Acid Transport Systems, BasicAmino Acid Transport System y+Amino Acid Transport System y+LAnimalsArginaseArginineAsthmaCationic Amino Acid Transporter 1CytokinesFemaleGene ExpressionImmunoglobulin EMacrophagesMiceMice, KnockoutAmino Acid Transport Systems, BasicAmino Acid Transport System y+Amino Acid Transport System y+LArg1 protein, mouseArg2 protein, mouseArginaseArginineCationic Amino Acid Transporter 1CytokinesImmunoglobulin ENitric Oxide Synthase Type IINos2 protein, mouseOvalbuminRNA, MessengerSlc7a1 protein, mouseSlc7a2 protein, mouseSlc7a7 protein, mouseAirway hyperresponsivenessArginase1Inflammation

Identifiers

PMID29183288
PMCPMC5706166
OpenAlexW2769820168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.