Evidence map›Paper›PMID 29183270›Full record

ArticleInternational journal of STD & AIDS2018

Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County.

Matthew R Beymer, Ryan M Kofron, Chi-Hong Tseng, Robert K Bolan, Risa P Flynn, Jennifer M Sayles, Mario J Perez, Wilbert C Jordan, Raphael J Landovitz

Open access · greenAbstract read
In one paragraph

Article in International journal of STD & AIDS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV - CDC Recommendations, United States, 2025.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2025
    Guideline
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Matthew R Beymer1 Los Angeles LGBT Center, Los Angeles, CA, USA.ORCID 0000-0001-5258-1095
Ryan M Kofron3 Center for Clinical AIDS Research & Education, Los Angeles, CA, USA.
Chi-Hong Tseng4 Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California, Los Angeles, CA, USA.
Robert K Bolan1 Los Angeles LGBT Center, Los Angeles, CA, USA.
Risa P Flynn1 Los Angeles LGBT Center, Los Angeles, CA, USA.
Jennifer M Sayles3 Center for Clinical AIDS Research & Education, Los Angeles, CA, USA.
Mario J Perez5 Division of HIV and STD Programs, Department of Public Health, County of Los Angeles, Los Angeles, CA, USA.
Wilbert C Jordan6 OASIS Clinic, Los Angeles, CA, USA.
Raphael J Landovitz2 Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA, USA.
APLA Health · USLos Angeles LGBT Center · USUniversity of California, Los Angeles · USLos Angeles County Department of Public Health · USOASIS Clinic · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Nina Thawata Harawa · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
NCATS NIH HHS UL1 TR001881NIAID NIH HHS P30 AI028697NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH080634
6 · The paper itself

Abstract

Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex with men (84%) and consisted overwhelmingly of a three-drug antiretroviral therapy regimen containing two nucleoside reverse transcriptase inhibitors and either an integrase inhibitor (raltegravir) or a boosted protease inhibitor (lopinavir/ritonavir). Approximately 64% of all PEP courses were followed for at least 12 weeks, and seven individuals seroconverted. Of the seven seroconversions, six had subsequent re-exposure. The low rate of PEP failure calls for expanded funding for PEP in other jurisdictions.

Indexed as

Homosexuality, MaleAdolescentAdultAnti-HIV AgentsFemaleHIV-1HIV InfectionsHumansLopinavirLos AngelesMaleMedication AdherenceMiddle AgedPilot ProjectsPost-Exposure ProphylaxisRaltegravir PotassiumAnti-HIV AgentsLopinavirRaltegravir PotassiumReverse Transcriptase InhibitorsRitonavirAntiretroviral therapyhigh-risk behaviorHIVhomosexualNorth America

Identifiers

PMID29183270
PMCPMC5843554
OpenAlexW2768725403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.