Evidence map›Paper›PMID 29182657›Full record

ArticlePloS one2017

Accuracy and reproducibility of CT right-to-left ventricular diameter measurement in patients with acute pulmonary embolism.

Yvonne M Ende-Verhaar, Lucia J M Kroft, Inge C M Mos, Menno V Huisman, Frederikus A Klok

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Prognostic Value of Right Ventricular Echocardiography on Mortality in Intermediate-Risk Hispanic Patients with Acute Pulmonary Embolism.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
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  6. Intervention Versus Medical Management of Pulmonary Embolism.Methodist DeBakey cardiovascular journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yvonne M Ende-VerhaarDepartment of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7357-9760
Lucia J M KroftDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Inge C M MosDepartment of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Menno V HuismanDepartment of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Frederikus A KlokDepartment of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight ventricular (RV) dysfunction caused by acute pulmonary embolism (PE) is associated with poor short- and long-term prognosis. RV dilatation as a proxy for RV dysfunction can be assessed by calculating the right-to-left ventricle diameter (RV/LV) ratio on standard computed tomography pulmonary angiography (CTPA) images. It is unknown whether dedicated training is required to accurately and reproducibly measure RV/LV ratio therefore we aimed to assess these parameters in residents in internal medicine without experience in CTPA reading.

methodsCTPA images of 100 patients with PE were assessed by three residents after single instruction, and one experienced thoracic radiologist. Maximum diameters were evaluated in the axial view by measuring the distance between the ventricular endocardium and the interventricular septum, perpendicular to the long axis of the heart. RV dilatation was defined as a ratio of ≥1.0. Interobserver accuracy and reproducibility was determined using Kappa statistics, Bland-Altman analysis and Spearman's rank correlation.

resultsThe kappa statistic for the presence of RV dilatation of the residents compared to the experienced radiologist ranged from 0.83-0.94. The average interobserver difference in calculated RV/LV ratio's (±SD) between the three residents was: -0.01 (SD0.11), 0.07 (SD0.14) and 0.06 (SD0.18) with an overall mean RV/LV diameter ratio of 1.04. In line with this, Spearman's rank correlation coefficients were 0.92, 0.88 and 0.85 respectively indicating very good correlation (p<0.01 for all).

conclusionAfter simple instruction, RV/LV diameter ratio assessment on CTPA images by clinical residents is accurate and reproducible, which is of help in identifying PE patients at risk.

Indexed as

Acute DiseaseAdultFemaleHumansMaleMiddle AgedPulmonary EmbolismReproducibility of ResultsTomography, X-Ray Computed

Identifiers

PMID29182657
PMCPMC5705138
OpenAlexW2768886616

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.