ArticleInternational journal of environmental research and public health2017
Oral Mucositis in Pediatric Patients in Treatment for Acute Lymphoblastic Leukemia.
Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06560879 (Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity and Changes in Gut Microbiota in Children With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity and Changes in Gut Microbiota in Children With Acute Lymphoblastic Leukemia
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis.Lasers in medical science · 2019Pooled it
- Healing Oral Mucositis WithBioMed research international · 2025Trial
- Pain Experiences During Early Treatment for Pediatric Acute Lymphoblastic Leukemia: A Qualitative Study.Psycho-oncology · 2026Article
- Assessment of Oral Health-Related Quality of Life in Children with Leukemia and Gingival Inflammation.Journal of personalized medicine · 2026Article
- Oral bacteriome in pediatric patients with malignancies prior to chemotherapy: a pilot study using full-length 16S rRNA sequencing.Frontiers in cellular and infection microbiology · 2026Article
- Gingivo-Periodontal Alterations in Pediatric Leukemia: A Comparative Analysis of IL-1β, IL-6, IL-17α and TGF-β1 Levels in Gingival Crevicular Fluid and Plasma.Dentistry journal · 2025Article
- The Role of miRNAs as Predictors of Acute Lymphoblastic Leukemia Chemotherapy Toxicity in Children: A Systematic Review.Journal of clinical medicine · 2025Review
- Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment.Frontiers in psychology · 2025Article
- Efficacy of palifermin in the treatment of oral mucositis in non-hematopoietic stem cell transplant pediatric patients: experience of a single tertiary hospital.Journal of the Egyptian National Cancer Institute · 2024Article
- Photobiomodulation for the prevention and treatment of oral mucositis in patients submitted to hematopoietic stem cell transplantation: health quality evaluation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Cross-cultural translation and modification of the revised oral assessment guide for oral health assessment by non-dentists.BDJ open · 2023Article
- Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia.BMC oral health · 2023Article
- The Implementation of an Integrated Oral Care Protocol for Pediatric Cancer Patients: a Qualitative Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023Article
- Genetic polymorphisms of genes involved in oxidative stress and inflammatory management in oncopediatric patients with chemo-induced oral mucositis.Journal of applied oral science : revista FOB · 2022Observational
- Use of Honey in the Management of Chemotherapy-Associated Oral Mucositis in Paediatric Patients.Cancer management and research · 2022Review
- Adolescents' understanding of chemotherapy-related adverse events: a concept elicitation study.Revista latino-americana de enfermagem · 2022Article
- The Parent-Child Patient Unit (PCPU): Evidence-Based Patient Room Design and Parental Distress in Pediatric Cancer Centers.International journal of environmental research and public health · 2021Article
- Integrated oral care contributes positively to the course of treatment of oncopediatric patients.European journal of pediatrics · 2021Article
- Medicinal Plants with Anti-Leukemic Effects: A Review.Molecules (Basel, Switzerland) · 2021Review
- Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy.Medicina oral, patologia oral y cirugia bucal · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral mucositis in oncologic patients is the most undesirable event of the chemotherapeutic treatment. This study aimed to identify damage to the oral cavity resulting from chemotherapy in pediatric patients with acute lymphoblastic leukemia (ALL). This is a prospective study with a sample of 42 children and adolescents evaluated for 10 consecutive weeks after diagnosis. The modified Oral Assessment Guide (OAG) was used, and data were analyzed by Spearman's rank correlation coefficient (α = 5%). Changes to the normal lips and saliva were positively related to an increase in the OAG score during all 10 weeks of evaluation. Alterations to the labial mucosa were correlated with an increase in the OAG score from the 2nd to 10th week, which was also found for changes in the tongue and in the swallowing function in Weeks 1, 6, 8, 9, and 10 and for gum changes from the 5th to 7th week. No significant vocal changes were correlated with the total OAG score at any point during the monitoring period. Changes in lips, cheek and/or palatal mucosa, labial mucosa, and gum areas and in swallowing function were positively correlated with an increase in the severity of oral mucositis in patients with ALL after beginning chemotherapeutic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.