ArticleMolecules (Basel, Switzerland)2017
Coumarin Derivatives Solvent-Free Synthesis under Microwave Irradiation over Heterogeneous Solid Catalysts.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 48 citations in OpenAlex.
- Drug Design of Carbonic Anhydrase Inhibitors.Sub-cellular biochemistry · 2026Review
- A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis.Scientific reports · 2025Article
- Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds.RSC advances · 2023Review
- Green construction of eco-friendly phosphotungstic acid Sr-MOF catalysts for crystal violet removal and synthesis of coumarin and xanthene compounds.RSC advances · 2021Article
- A review on convenient synthesis of substituted coumarins using reuseable solid acid catalysts.RSC advances · 2021Review
- FeMolecular diversity · 2021Article
- Design and synthesis of coumarin-triazole hybrids: biocompatible anti-diabetic agents,Heliyon · 2020Article
- An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities.International journal of molecular sciences · 2020Review
- Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials.Biomolecules · 2020Review
- One-Pot Syntesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions.Molecules (Basel, Switzerland) · 2018Article
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7 authors at 1 institution in 2 countries.
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Abstract
A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials-Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica-in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions.
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