Trial reportClinical gerontologist
Multimedia Aided Consent for Alzheimer's Disease Research.
Trial report in Clinical gerontologist. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00453544 (Enhancing Consent for Alzheimer's Research), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing Consent for Alzheimer's Research
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Consent for Research Involving Spanish- and English-Speaking Latinx Adults With Schizophrenia.Schizophrenia bulletin · 2024Trial
- Medical Decision-Making Capacity in Early-Stage Alzheimer Patients: Comparison With Healthy Controls and Benefit of Assistive Information.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Informed Consent or Assent Strategies for Research With Individuals With Deafblindness or Dual Sensory Impairment: A Scoping Review.Archives of rehabilitation research and clinical translation · 2021Article
- Decision-Making Support for People With Alzheimer's Disease: A Narrative Review.Frontiers in psychology · 2021Review
- Determining medical decision-making capacity in brain tumor patients: why and how?Neuro-oncology practice · 2020Review
- Informed consent, therapeutic misconception, and clinical trials for Alzheimer's disease.International journal of geriatric psychiatry · 2020Article
- Planning Ahead for Dementia Research Participation: Insights from a Survey of Older Australians and Implications for Ethics, Law and Practice.Journal of bioethical inquiry · 2019Article
- Developing, Implementing, and Evaluating a Multimedia Patient Decision Aid Program to Reform the Informed Consent Process of a Peripherally Inserted Central Venous Catheter Procedure: Protocol for Quality Improvement.JMIR research protocols · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesOptimizing the research consent process simultaneously fosters respect for autonomy and protection of those with diminished capacity for autonomy. This study evaluated the effectiveness of an enhanced research consent procedure, employing multimedia disclosure and corrective feedback, in improving decisional capacity among 114 people with mild-to-moderate Alzheimer's disease (AD) and 134 non-psychiatric comparison (NC) subjects.
methodsParticipants were randomized to consent type (routine versus enhanced) and protocol type (lower versus higher risk). Outcomes included a 5-item questionnaire assessing immediate comprehension, MacArthur Competence Assessment Tool for Clinical Research assessing four components of decision-making capacity, and categorical decisional capacity (based on a cut-score established in reference to expert judgments for a subset of participants).
resultsThere was no significant effect of the enhanced consent procedure, relative to routine consent, on immediate comprehension or decisional capacity.
conclusionsMultimedia tools do not appear to be the solution to better consent for AD research. CLINICAL IMPLICATIONS: Given the ethical primacy of informed consent and issues of justice for impaired populations who might be harmed by an absence of research-based treatment advances, continued search for ways to more meaningfully engage people with AD in the consent or assent process is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.