ArticleeLife2017
Rapid re-identification of human samples using portable DNA sequencing.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Cell line authentication using optical genome mapping.BMC genomics · 2025Article
- NASTRA: accurate analysis of short tandem repeat markers by nanopore sequencing with repeat-structure-aware algorithm.Briefings in bioinformatics · 2024Article
- Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine.Frontiers in medicine · 2024Article
- High resolution copy number inference in cancer using short-molecule nanopore sequencing.Nucleic acids research · 2021Article
- Enhanced mixture interpretation with macrohaplotypes based on long-read DNA sequencing.International journal of legal medicine · 2021Article
- Nanopore sequencing technology, bioinformatics and applications.Nature biotechnology · 2021Review
- Transposable element profiles reveal cell line identity and loss of heterozygosity in Drosophila cell culture.Genetics · 2021Article
- Privacy practices using genetic data from cell-free DNA aneuploidy screening.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Article
- Authentication, characterization and contamination detection of cell lines, xenografts and organoids by barcode deep NGS sequencing.NAR genomics and bioinformatics · 2020Article
- The interface of genomic information with the electronic health record: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG).Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Massive parallel sequencing in forensics: advantages, issues, technicalities, and prospects.International journal of legal medicine · 2020Review
- Approaching RNA-seq for Cell Line Identification.Bio-protocol · 2020Article
- Current Progression: Application of High-Throughput Sequencing Technique in Space Microbiology.BioMed research international · 2020Review
- Unlocking the Power of Artificial Intelligence and Big Data in Medicine.Journal of medical Internet research · 2019Article
- CeL-ID: cell line identification using RNA-seq data.BMC genomics · 2019Article
- Robust in-silico identification of Cancer Cell Lines based on RNA and targeted DNA sequencing data.Scientific reports · 2019Article
- Massively parallel sequencing techniques for forensics: A review.Electrophoresis · 2018Review
- DNA makes an appearance.Nature biotechnology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA re-identification is used for a broad suite of applications, ranging from cell line authentication to forensics. However, current re-identification schemes suffer from high latency and limited access. Here, we describe a rapid, inexpensive, and portable strategy to robustly re-identify human DNA called 'MinION sketching'. MinION sketching requires as few as 3 min of sequencing and 60-300 random SNPs to re-identify a sample enabling near real-time applications of DNA re-identification. Our method capitalizes on the rapidly growing availability of genomic reference data for cell lines, tissues in biobanks, and individuals. This empowers the application of MinION sketching in research and clinical settings for periodic cell line and tissue authentication. Importantly, our method enables considerably faster and more robust cell line authentication relative to current practices and could help to minimize the amount of irreproducible research caused by mix-ups and contamination in human cell and tissue cultures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.