Evidence map›Paper›PMID 29181834›Full record

ArticleDrug delivery and translational research2018

Ion-pair formation combined with a penetration enhancer as a dual strategy to improve the transdermal delivery of meloxicam.

Qikun Jiang, Jin Wang, Panqin Ma, Cuiru Liu, Mengchi Sun, Yinghua Sun, Zhonggui He

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qikun JiangDepartment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China.
Jin WangDepartment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China.
Panqin MaKangya of Ningxia Pharmaceuticals CO. LTD, Yinchuan, China.
Cuiru LiuDepartment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China.
Mengchi SunDepartment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China.
Yinghua SunDepartment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China. sunyinghua77@aliyun.com.
Zhonggui HeDepartment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Mailbox 59#, No. 103 Wenhua Road, Shenyang, 110016, China. hezhgui_student@aliyun.com.
Shenyang Pharmaceutical University · CN

Funding

the National Science and Technology Major Project of China No.2014zx09507001-009
6 · The paper itself

Abstract

The aim of the study was to develop a novel drug-in-adhesive patch for transdermal delivery of meloxicam (MLX). The formulation involved a strategy to combine a chemical enhancer with an ion-pair agent. Diethylamine (DETA) was selected as the counter ion to form the ion-pair agent MLX-DETA. MLX-DETA was characterized by nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FTIR). The ion-pair lifetime (T

Indexed as

AdhesivesAdministration, CutaneousAnimalsAnti-Inflammatory Agents, Non-SteroidalDiethylaminesDrug LiberationMaleMeloxicamMusclesOleic AcidPermeabilityRabbitsRats, Sprague-DawleySkinSkin AbsorptionSkin Irritancy TestsAdhesivesAnti-Inflammatory Agents, Non-SteroidaldiethylamineDiethylaminesMeloxicamOleic AcidThiazinesThiazolesIon-pair formationMeloxicamPermeation enhancerTissue distributionTransdermal drug delivery

Identifiers

PMID29181834
OpenAlexW2769644498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.