Evidence map›Paper›PMID 29181816›Full record

Trial reportPsychopharmacology2018

Nicotine-induced activation of caudate and anterior cingulate cortex in response to errors in schizophrenia.

Lauren V Moran, Luke E Stoeckel, Kristina Wang, Carolyn E Caine, Rosemond Villafuerte, Vanessa Calderon, Justin T Baker, Dost Ongur, Amy C Janes, A Eden Evins and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lauren V MoranMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA. lmoran4@partners.org.
Luke E StoeckelDepartment of Psychiatry, Harvard Medical School, Belmont, MA, 02478, USA.
Kristina WangMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
Carolyn E CaineMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
Rosemond VillafuerteMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
Vanessa CalderonDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.
Justin T BakerMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
Dost OngurMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
Amy C JanesMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
A Eden EvinsDepartment of Psychiatry, Harvard Medical School, Belmont, MA, 02478, USA.
Diego A PizzagalliMcLean Hospital, 115 Mill Street, AB3S, Belmont, MA, 02478, USA.
McLean Hospital · USHarvard University · USMassachusetts General Hospital · US

Funding

Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Neuroimaging Studies of Reward Processing in DepressionR01MH068376 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2004 to 2014
$4.5M
Mentoring in Addiction Treatment ResearchK24DA030443 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI EVINS, A EDEN · 2010 to 2020
$2.0M
Frontoparietal Network Integrity and Risk for PsychosisK23MH104515 · NIMH · MCLEAN HOSPITAL · PI BAKER, JUSTIN T · 2014 to 2018
$907k
Risk of Psychosis with Prescription Stimulant UseK23MH110564 · NIMH · MCLEAN HOSPITAL · PI MORAN, LAUREN V · 2017 to 2020
$790k
National Alliance for Research on Schizophrenia and Depression 20558NIDA NIH HHS K24 DA030443NIMH NIH HHS K23 MH104515NIMH NIH HHS K23 MH110564NIMH NIH HHS R01 MH068376NIMH NIH HHS R37 MH068376
6 · The paper itself

Abstract

backgroundNicotine improves attention and processing speed in individuals with schizophrenia. Few studies have investigated the effects of nicotine on cognitive control. Prior functional magnetic resonance imaging (fMRI) research demonstrates blunted activation of dorsal anterior cingulate cortex (dACC) and rostral anterior cingulate cortex (rACC) in response to error and decreased post-error slowing in schizophrenia.

methodsParticipants with schizophrenia (n = 13) and healthy controls (n = 12) participated in a randomized, placebo-controlled, crossover study of the effects of transdermal nicotine on cognitive control. For each drug condition, participants underwent fMRI while performing the stop signal task where participants attempt to inhibit prepotent responses to "go (motor activation)" signals when an occasional "stop (motor inhibition)" signal appears. Error processing was evaluated by comparing "stop error" trials (failed response inhibition) to "go" trials. Resting-state fMRI data were collected prior to the task.

resultsParticipants with schizophrenia had increased nicotine-induced activation of right caudate in response to errors compared to controls (DRUG × GROUP effect: p

conclusionsIn sum, we replicated prior findings of decreased post-error slowing in schizophrenia and found that nicotine was associated with more adaptive (i.e., increased) post-error reaction time (RT). This proof-of-concept pilot study suggests a role for nicotinic agents in targeting cognitive control deficits in schizophrenia.

Indexed as

AdolescentAdultAttentionCase-Control StudiesCaudate NucleusCognitionCross-Over StudiesFemaleGyrus CinguliHumansInhibition, PsychologicalMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityNicotineNicotineNicotinic AgonistsAnterior cingulateCaudateErrorFunctional magnetic resonance imagingSchizophrenia

Identifiers

PMID29181816
PMCPMC5823729
OpenAlexW2769630167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.