ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2018
A Novel Translational Model of Spinal Cord Injury in Nonhuman Primate.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Novel Full-Length Dissection of the Sympathetic Chain and Spinal Cord From T1-L1 in a Human Cadaver.Cureus · 2026Article
- Advances in Intranasal Delivery of Exosomes for Central Nervous System Disorders.Molecular neurobiology · 2025Review
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- Sex and age differences in glia and myelin in nonhuman primate and human spinal cords: implications for pathology.Cell death discovery · 2025Article
- Intranasal Delivery of Brain-Derived Neurotrophic Factor (BDNF)-Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys.Journal of extracellular vesicles · 2025Article
- Activation of FANCC attenuates mitochondrial ROS-driven necroptosis by targeting TBK1-dependent mitophagy in astrocytes after spinal cord injury.Theranostics · 2025Article
- Review
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Quantification of early gait development: Expanding the application of Catwalk technology to an infant rhesus macaque model.Journal of neuroscience methods · 2023Article
- Development, refinement, and characterization of a nonhuman primate critical care environment.PloS one · 2023Article
- Unlike Brief Inhibition of Microglia Proliferation after Spinal Cord Injury, Long-Term Treatment Does Not Improve Motor Recovery.Brain sciences · 2021Article
- The MAPK Signaling Pathway Presents Novel Molecular Targets for Therapeutic Intervention after Traumatic Spinal Cord Injury: A Comparative Cross-Species Transcriptional Analysis.International journal of molecular sciences · 2021Article
- Review
- How to generate graded spinal cord injuries in swine - tools and procedures.Disease models & mechanisms · 2021Article
- Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury.Frontiers in aging neuroscience · 2021Review
- Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates.Theranostics · 2021Article
- Progress in Understanding Ferroptosis and Its Targeting for Therapeutic Benefits in Traumatic Brain and Spinal Cord Injuries.Frontiers in cell and developmental biology · 2021Review
- Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Use of longitudinal magnetic resonance imaging in preclinical models of spinal cord injury.Neural regeneration research · 2019Article
- Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities.Frontiers in aging neuroscience · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injuries (SCI) lead to major disabilities affecting > 2.5 million people worldwide. Major shortcomings in clinical translation result from multiple factors, including species differences, development of moderately predictive animal models, and differences in methodologies between preclinical and clinical studies. To overcome these obstacles, we first conducted a comparative neuroanatomical analysis of the spinal cord between mice, Microcebus murinus (a nonhuman primate), and humans. Next, we developed and characterized a new model of lateral spinal cord hemisection in M. murinus. Over a 3-month period after SCI, we carried out a detailed, longitudinal, behavioral follow-up associated with in vivo magnetic resonance imaging (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.