Evidence map›Paper›PMID 29181743›Full record

ReviewBiophysical reviews2018

Molecular dynamics simulation of bacterial flagella.

Akio Kitao, Hiroaki Hata

Open access · greenAbstract readReview
In one paragraph

Review in Biophysical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Stochastic motility energetics reveals cooperative bacterial swarming in optical tweezers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. A simple cost-effective method for purification ofVeterinary research forum : an international quarterly journal · 2025
    Article
  3. Article
  4. International journal of molecular sciences · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Akio KitaoSchool of Life Science and Technology, Tokyo Institute of Technology, M6-13, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan. akitao@bio.titech.ac.jp.ORCID http://orcid.org/0000-0002-5221-0806
Hiroaki HataInstitute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPTokyo Institute of Technology · JP

Funding

Japan Society for the Promotion of Science 15H04357Japan Society for the Promotion of Science 25104002Ministry of Education, Culture, Sports, Science and Technology Priority Issue on Post-K Computer (Building Innovative Drug Discovery Infrastructure Through Functional Control of Biomolecular Systems)
6 · The paper itself

Abstract

The bacterial flagellum is a biological nanomachine for the locomotion of bacteria, and is seen in organisms like Salmonella and Escherichia coli. The flagellum consists of tens of thousands of protein molecules and more than 30 different kinds of proteins. The basal body of the flagellum contains a protein export apparatus and a rotary motor that is powered by ion motive force across the cytoplasmic membrane. The filament functions as a propeller whose helicity is controlled by the direction of the torque. The hook that connects the motor and filament acts as a universal joint, transmitting torque generated by the motor to different directions. This report describes the use of molecular dynamics to study the bacterial flagellum. Molecular dynamics simulation is a powerful method that permits the investigation, at atomic resolution, of the molecular mechanisms of biomolecular systems containing many proteins and solvent. When applied to the flagellum, these studies successfully unveiled the polymorphic supercoiling and transportation mechanism of the filament, the universal joint mechanism of the hook, the ion transfer mechanism of the motor stator, the flexible nature of the transport apparatus proteins, and activation of proteins involved in chemotaxis.

Indexed as

ChemotaxisIon transportMolecular dynamicsPolymorphic supercoilingProtein exportUniversal joint

Identifiers

PMID29181743
PMCPMC5899699
OpenAlexW2769743044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.