Trial reportLasers in medical science2018
Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers.
Trial report in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- The Effect of Photobiomodulation in the Management of Leg Ulcers in Sickle Cell Disease: A Systematic Review.International wound journal · 2026Pooled it
- Effectiveness of electrophysical agents for treating pressure injuries: a systematic review.Lasers in medical science · 2022Pooled it
- Impact of photobiomodulation on macrophages and their polarization during diabetic wound healing: a systematic review.Lasers in medical science · 2022Pooled it
- Trial
- The effects of intravenous laser irradiation of blood with red and blue light on stroke risk biomarkers and neurological function: a double blind randomized controlled trial.Lasers in medical science · 2025Trial
- Effects of myotherapy combined with photobiomodulation on the lips: a randomized clinical trial.CoDAS · 2025Trial
- Effect of laser therapy on expression of angio- and fibrogenic factors, and cytokine concentrations during the healing process of human pressure ulcers.International journal of medical sciences · 2018Trial
- Effect of photobiomodulation therapy on regulating reparative processes of chronic wounds at the inflammation stageBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Evaluation of lighted catheter phototherapy in endoscopic treatment of urethral strictures: a rabbit pilot study.International urology and nephrology · 2026Article
- Photobiomodulation Reduces Fibrous Scar Formation After Spinal Cord Injury by Downregulating CXCL3 Expression in Macrophages.Molecular neurobiology · 2025Article
- Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation.Lasers in medical science · 2025Review
- Effect of Novel Laser Shoe Photobiomodulation on Neuropathic Pain and Plantar Pressure Profile in Type 2 Diabetes Mellitus with Peripheral Neuropathy.Current diabetes reviews · 2025Article
- Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing.The American journal of case reports · 2024Article
- Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization.Frontiers in endocrinology · 2024Review
- Photobiomodulation at molecular, cellular, and systemic levels.Lasers in medical science · 2023Review
- Low-Level Laser Therapy Induces Melanoma Tumor Growth by Promoting Angiogenesis.Life (Basel, Switzerland) · 2023Article
- Microplastics Affect the Inflammation Pathway in Human Gingival Fibroblasts: A Study in the Adriatic Sea.International journal of environmental research and public health · 2022Article
- Laser-photobiomodulation on titanium implant bone healing in rat model: comparison between 660- and 808-nm wavelength.Lasers in medical science · 2022Article
- Effects of photobiomodulation on glucose homeostasis and morphometric parameters in pancreatic islets of diabetic mice.Lasers in medical science · 2022Article
- Photobiomodulation exerts anti-inflammatory effects on the vascular and cellular phases of experimental inflammatory models.Lasers in medical science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pressure ulcers (PU) are wounds located mainly on bone surfaces where the tissue under pressure suffers ischemia leading to cellular lesion and necrosis , its causes and the healing process depend on several factors. The aim of this study was evaluating the gene expression of inflammatory/reparative factors: IL6, TNF, VEGF, and TGF, which take part in the tissue healing process under effects of low-level laser therapy (LLLT). In order to perform lesion area analysis, PUs were photographed and computer analyzed. Biochemical analysis was performed sa.mpling ulcer border tissue obtained through biopsy before and after laser therapy and quantitative real-time PCR (qRT-PCR) analysis. The study comprised eight individuals, mean age sixty-two years old, and sacroiliac and calcaneous PU, classified as degree III and IV according to the National Pressure Ulcer Advisory Panel (NPUAP). PUs were irradiated with low-level laser (InGaAIP, 100 mW, 660 nm), energy density 2 J/cm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.