ArticleAMB Express2017
Strategies for improving production performance of probiotic Pediococcus acidilactici viable cell by overcoming lactic acid inhibition.
Article in AMB Express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
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- Isolation and Characterization of Effective Bacteria That Reduce Ammonia Emission from Livestock Manure.Microorganisms · 2021Article
- Fermented dairy products as delivery vehicles of novel probiotic strains isolated from traditional fermented Asian foods.Journal of food science and technology · 2021Review
- Lactic acid separation and recovery from fermentation broth by ion-exchange resin: A review.Bioresources and bioprocessing · 2021Review
- Genomic Insight intoMicroorganisms · 2020Article
- Optimization of Protective Agents for The Freeze-Drying ofMolecules (Basel, Switzerland) · 2020Article
- Optimization of Production Parameters for Probiotic Lactobacillus Strains as Feed Additive.Molecules (Basel, Switzerland) · 2019Article
- Microencapsulation ofMolecules (Basel, Switzerland) · 2019Article
- Characterization, yield optimization, scale up and biopreservative potential of fermencin SA715, a novel bacteriocin from Lactobacillus fermentum GA715 of goat milk origin.Microbial cell factories · 2018Article
- Stability of Bacteriocin-Like Inhibitory Substance (BLIS) Produced byBioMed research international · 2018Article
- Growth Enhancement of ProbioticFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lactic acid bacteria are industrially important microorganisms recognized for fermentative ability mostly in their probiotic benefits as well as lactic acid production for various applications. Fermentation conditions such as concentration of initial glucose in the culture, concentration of lactic acid accumulated in the culture, types of pH control strategy, types of aeration mode and different agitation speed had influenced the cultivation performance of batch fermentation of Pediococcus acidilactici. The maximum viable cell concentration obtained in constant fed-batch fermentation at a feeding rate of 0.015 L/h was 6.1 times higher with 1.6 times reduction in lactic acid accumulation compared to batch fermentation. Anion exchange resin, IRA 67 was found to have the highest selectivity towards lactic acid compared to other components studied. Fed-batch fermentation of P. acidilactici coupled with lactic acid removal system using IRA 67 resin showed 55.5 and 9.1 times of improvement in maximum viable cell concentration compared to fermentation without resin for batch and fed-batch mode respectively. The improvement of the P. acidilactici growth in the constant fed-batch fermentation indicated the use of minimal and simple process control equipment is an effective approach for reducing by-product inhibition. Further improvement in the cultivation performance of P. acidilactici in fed-bath fermentation with in situ addition of anion-exchange resin significantly helped to enhance the growth of P. acidilactici by reducing the inhibitory effect of lactic acid and thus increasing probiotic production.
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Registered trials
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