Evidence map›Paper›PMID 29181578›Full record

GuidelineArchives of gynecology and obstetrics2018

Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part II: fertility preservation techniques.

Michael von Wolff, A Germeyer, J Liebenthron, M Korell, F Nawroth

Open access · hybridAbstract readGuideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Archives of gynecology and obstetrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Michael von WolffDivision of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Berne, Berne, Switzerland. Michael.vonWolff@insel.ch.ORCID 0000-0003-4303-2734
A GermeyerDepartment of Gynaecological Endocrinology and Fertility Disorders, Medical University of Heidelberg, Heidelberg, Germany.
J LiebenthronDepartment of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Bonn, Bonn, Germany.
M KorellDepartment of Obstetrics and Gynaecology, Johanna Etienne Hospital of Neuss, Neuss, Germany.
F NawrothCentre for Infertility, Prenatal Medicine, Endocrinology and Osteology, Amedes Hamburg, Hamburg, Germany.
Amedes MVZ Hamburg · DEHeidelberg University · DEJohanna-Etienne-Krankenhaus · DEUniversity of Bern · CHUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn addition to guidelines focusing on scientific evidence, practical recommendations on fertility preservation are also needed.

methodsA selective literature search was performed based on the clinical and scientific experience of the authors. This article (Part II) focuses on fertility preservation techniques. Part I, also published in this journal, provides information on disease prognosis, disease-specific therapy, and risks for loss of fertility.

resultsOvarian stimulation including double stimulation and freezing of oocytes is the best-established therapy providing live birth chances in women < 35 years with high ovarian reserve of around 30-40%. Ovarian tissue freezing is especially useful in young women with good ovarian, if spontaneous conception is favoured and if < 1 week until chemotherapy is provided. Data on success rates are still limited, but this further evolving technique will possibly reach similar success rates as ovarian stimulation. GnRH agonists seem to reduce the risk of premature ovarian failure up to 50%; however, the effect is possibly not long-lasting. Ovarian transposition can easily be combined with freezing of ovarian tissue and is the preferred technique before pelvic radiotherapy. Other techniques, such as in vitro maturation, are limited to women with high ovarian reserve and remain less effective. In addition, procedures such as in vitro growth of follicles, etc. are still experimental.

conclusionsFertility preservation in women provides realistic chances of becoming pregnant. The choice of technique needs to be based on the time required, the woman's age, its risks and efficacy, and the individual preference of the patient.

Indexed as

AdultFemaleFertility PreservationHumansOvulation InductionProspective StudiesYoung AdultFertility preservationGnRH agonistsOocyte ovarian stimulationOvarian tissue

Identifiers

PMID29181578
PMCPMC5762782
OpenAlexW2768600722

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.