ArticleFrontiers in oncology2017
Perceived Workplace Stress Is Associated with an Increased Risk of Prostate Cancer before Age 65.
Article in Frontiers in oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis.Oxidative medicine and cellular longevity · 2019Pooled it
- The crosstalk between nerves and immunity: chronic stress as a driver of tumor progression.Frontiers in immunology · 2026Review
- Burnout Syndrome in Work from Home Settings during the Second Wave of the COVID-19 Pandemic: A Cross-sectional Study.Acta medica Philippina · 2026Article
- Allostatic load and risk of prostate cancer in UK Biobank.Scientific reports · 2025Article
- Chronic stress: a fourth etiology in tumorigenesis?Molecular cancer · 2025Review
- Firefighting, other protective service occupations and prostate cancer risk: a pooled analysis of three case-control studies.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Sick Leave due to Stress and Subsequent Cancer Risk, a Swedish National Registry Study of 516,678 Cancer Cases.Cancer medicine · 2025Article
- The Crosstalk between Nerves and Cancer-A Poorly Understood Phenomenon and New Possibilities.Cancers · 2024Review
- Non-surgical nursing care for tumor patients: an overview of sedation, analgesia, and recent innovations.Frontiers in oncology · 2024Review
- Unmasking the Hidden Danger: A Decade-Long Systematic Review of Case-Control Studies on Single Occupational Risks and Prostate Cancer.Life (Basel, Switzerland) · 2023Review
- Occupation and prostate Cancer risk: results from the epidemiological study of prostate cancer (EPICAP).Journal of occupational medicine and toxicology (London, England) · 2022Article
- The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms.Cancer research · 2021Review
- Review
- Illuminating Neuroimmunity: A Humoral Brain.Immunity · 2020Article
- β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells.BMC cancer · 2019Article
- Socioenvironmental adversity and risk of prostate cancer in non-Hispanic black and white men.Cancer causes & control : CCC · 2019Article
- Preventive care service use among cancer survivors with serious psychological distress: An analysis of the medical expenditure panel survey data.Preventive medicine · 2019Article
- Prostate cancer risk by occupation in the Occupational Disease Surveillance System (ODSS) in Ontario, Canada.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2019Article
- Sleep disorders associated with risk of prostate cancer: a population-based cohort study.BMC cancer · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence is lacking regarding the potential role of chronic psychological stress on cancer incidence. The workplace is reported to be the main source of stress among Canadian men. We examined the association between perceived lifetime workplace stress and prostate cancer (PCa) risk in a large case-control study.
methodsCases were 1,933 men, aged ≤ 75 years, newly diagnosed with PCa in 2005-2009 across hospitals in Montreal, Canada. Concurrently, 1994 population controls frequency-matched on age were randomly selected from the electoral list based on cases' residential districts. Detailed lifestyle and work histories (including perceived stress, from any type of work stressor, for each job held) were collected during in-person interviews. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between work-related stress and PCa risk in multivariate analyses.
resultsOver the lifetime, 58% of subjects reported at least one job as stressful. Occupations described as stressful were most often among white-collar workers. Perceived workplace stress duration was associated with a higher risk of PCa (OR = 1.12, 95% CI:1.04-1.20 per 10-year increase) among men younger than 65 years, but not among older men. Associations were similar irrespective of PCa aggressiveness. Frequent or recent screening for PCa, age at first exposure and time since exposure to work-related stress, and socioeconomic and lifestyle factors, had little influence on risk estimates.
conclusionFindings are in line with an association between reporting prolonged workplace stress and an increase in risk of PCa before age 65.
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