Evidence map›Paper›PMID 29181111›Full record

ArticleBeilstein journal of organic chemistry2017

Homologated amino acids with three vicinal fluorines positioned along the backbone: development of a stereoselective synthesis.

Raju Cheerlavancha, Ahmed Ahmed, Yun Cheuk Leung, Aggie Lawer, Qing-Quan Liu, Marina Cagnes, Hee-Chan Jang, Xiang-Guo Hu, Luke Hunter

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In one paragraph

Article in Beilstein journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raju CheerlavanchaSchool of Chemistry, The University of New South Wales, Sydney NSW 2052, Australia.
Ahmed AhmedSchool of Chemistry, The University of New South Wales, Sydney NSW 2052, Australia.
Yun Cheuk LeungSchool of Chemistry, The University of New South Wales, Sydney NSW 2052, Australia.
Aggie LawerSchool of Chemistry, The University of New South Wales, Sydney NSW 2052, Australia.
Qing-Quan LiuNational Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, China.
Marina CagnesSchool of Chemistry, The University of Sydney, Sydney NSW 2006, Australia.
Hee-Chan JangSchool of Chemistry, The University of Sydney, Sydney NSW 2006, Australia.
Xiang-Guo HuNational Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, China.
Luke HunterSchool of Chemistry, The University of New South Wales, Sydney NSW 2052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backbone-extended amino acids have a variety of potential applications in peptide and protein science, particularly if the geometry of the amino acid is controllable. Here we describe the synthesis of δ-amino acids that contain three vicinal C-F bonds positioned along the backbone. The ultimately successful synthetic approach emerged through the investigation of several methods based on both electrophilic and nucleophilic fluorination chemistry. We show that different diastereoisomers of this fluorinated δ-amino acid adopt distinct conformations in solution, suggesting that these molecules might have value as shape-controlled building blocks for future applications in peptide science.

Indexed as

amino acidsconformationdeoxyfluorinationfluorinestereochemistry

Identifiers

PMID29181111
PMCPMC5687047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.