Evidence map›Paper›PMID 29181084›Full record

ArticlePersonalized medicine2017

Clinical pharmacogenomics: patient perspectives of pharmacogenomic testing and the incidence of actionable test results in a chronic disease cohort.

Chandrama Mukherjee, Kevin M Sweet, Jasmine A Luzum, Mahmoud Abdel-Rasoul, Michael F Christman, Joseph P Kitzmiller

Open access · greenAbstract read
In one paragraph

Article in Personalized medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Moving Pharmacogenetics Into Practice: It's All About the Evidence!Clinical pharmacology and therapeutics · 2021
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chandrama MukherjeeDepartment of Biological Chemistry & Pharmacology, Ohio State University, Columbus, OH 43210, USA.
Kevin M SweetDivision of Human Genetics, Ohio State University, Columbus, OH 43210, USA.
Jasmine A LuzumDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Mahmoud Abdel-RasoulCenter for Biostatistics, College of Medicine, Ohio State University, 1800 Cannon Drive Columbus, OH 43210, USA.
Michael F ChristmanCoriell Institute for Medical Research, Camden, NJ 08103, USA.
Joseph P KitzmillerDepartment of Biological Chemistry & Pharmacology, Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · USCoriell Institute For Medical Research · USUniversity of Michigan–Ann Arbor · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Statin Pharmacogenomics: A multi-gene PK-PD modeling approachK23GM100372 · NIGMS · OHIO STATE UNIVERSITY · PI KITZMILLER, JOSEPH PAUL · 2011 to 2015
$955k
Assessing the utility of genomic counseling for common complex diseasesR21HG006575 · NHGRI · OHIO STATE UNIVERSITY · PI CHRISTMAN, MICHAEL F, SWEET, KEVIN M. · 2013 to 2014
$477k
NCATS NIH HHS UL1 TR001070NHGRI NIH HHS R21 HG006575NHLBI NIH HHS L30 HL110279NIGMS NIH HHS K23 GM100372NIMHD NIH HHS L32 MD006365
6 · The paper itself

Abstract

aimThis study aimed to examine pharmacogenomic test results and patient perspectives at an academic cardiovascular medicine clinic. PATIENTS &

methodsTest results for three common cardiovascular drug-gene tests (warfarin-

resultsPotentially actionable test results for at least one of the three drug-gene tests were determined in 170 (82%) patients. Survey responses (n = 134) suggested that patients generally considered their test results to be important (median of 7.5 on a 10-point scale of importance) and were interested (median of 7.3 on a 10-point scale of interest) in a Clinical Pharmacogenomic Service.

conclusionAttitudes toward pharmacogenomic testing were generally favorable, and potentially actionable test results were not uncommon in this cardiovascular medicine cohort.

Indexed as

actionable test resultscardiovascular drugsclopidogrelpatient perspectivespersonalized medicinepharmacogeneticspharmacogenomicsprecision medicinesimvastatinwarfarin

Identifiers

PMID29181084
PMCPMC5696621
OpenAlexW2750800610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.