Evidence map›Paper›PMID 29181068›Full record

ArticleArchives of medical science : AMS2017

Immunohistochemical features and staging of early gastric cancer.

Simona Gurzu, Janina Orlowska, Haruhiko Sugimura, Tivadar Bara, Zoltan Szentirmay, Wladyslaw Januszewicz, Tivadar Bara, Janos Szederjesi, Ioan Jung

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Simona GurzuUniversity of Medicine and Pharmacy, Tirgu-Mureş, Romania.
Janina OrlowskaMaria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
Haruhiko SugimuraHamamatsu University School of Medicine, Hamamatsu, Japan.
Tivadar BaraUniversity of Medicine and Pharmacy, Tirgu-Mureş, Romania.
Zoltan SzentirmayNational Institute of Oncology, Budapest, Hungary.
Wladyslaw JanuszewiczMaria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
Tivadar BaraUniversity of Medicine and Pharmacy, Tirgu-Mureş, Romania.
Janos SzederjesiUniversity of Medicine and Pharmacy, Tirgu-Mureş, Romania.
Ioan JungUniversity of Medicine and Pharmacy, Tirgu-Mureş, Romania.
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROHamamatsu University School of Medicine · JPNational Institute of Oncology · HUThe Maria Sklodowska-Curie National Research Institute of Oncology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to analyze the particularities of early gastric cancer (EGC) and their importance for staging, prognosis, and therapy. MATERIAL AND

methodsA total of 338 GCs diagnosed and surgically removed in three medical institutes from Eastern Europe were retrospectively examined, and the EGCs were further examined. Besides the demographic factors and tumor characteristics, immunostains were performed with E-cadherin, HER-2, p53, Ki67, MLH-1, MSH-2, COX-2, VEGF-A, CD31, and CD105.

resultsFrom the 338 GCs, 29 were EGCs, the average being similar in Poland and Hungary (12.37% and 13.33% respectively) but lower in Romania (5.61%). The rate of lymph node metastases was 20.69% (

conclusionsIn EGCs, intramural carcinomatosis of the lymph vessels and multifocality should be separately described in every surgical pathology report, as indicators of aggressiveness. Microsatellite status, E-cadherin, HER-2, p53, and Ki67 do not have prognostic value in EGC, but the highly angiogenic pattern is a possible therapeutic target.

Indexed as

angiogenesiscarcinomatosiscarcinomatous lymphangitisearly gastric cancerstaging

Identifiers

PMID29181068
PMCPMC5701676
OpenAlexW2394899153

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.