Evidence map›Paper›PMID 29181035›Full record

ReviewStem cells international2017

The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche.

Cosette M Rivera-Cruz, Joseph J Shearer, Manoel Figueiredo Neto, Marxa L Figueiredo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cosette M Rivera-CruzDepartment of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.ORCID 0000-0001-5487-0106
Joseph J ShearerDepartment of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
Manoel Figueiredo NetoDepartment of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
Marxa L FigueiredoDepartment of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.ORCID 0000-0002-8134-0749

Funding

Preventing prostate cancer progression by ASC delivery of PEDF and IFNbR21CA153165 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FIGUEIREDO, MARXA L · 2012 to 2013
$428k
NCI NIH HHS R21 CA153165
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) represent a promising tool for cell therapy, particularly for their antitumor effects. This cell population can be isolated from multiple tissue sources and also display an innate ability to home to areas of inflammation, such as tumors. Upon entry into the tumor microenvironment niche, MSCs promote or inhibit tumor progression by various mechanisms, largely through the release of soluble factors. These factors can be immunomodulatory by activating or inhibiting both the adaptive and innate immune responses. The mechanisms by which MSCs modulate the immune response are not well understood. Because of this, the relationship between MSCs and immune cells within the tumor microenvironment niche continues to be an active area of research in order to help explain the apparent contradictory findings currently available in the literature. The ongoing research aims to enhance the potential of MSCs in future therapeutic applications.

Identifiers

PMID29181035
PMCPMC5664329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.